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Title: Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men
Author: Killick, Emma
Morgan, Richard
Launchbury, Francesca
Bancroft, Elizabeth
Page, Elizabeth
Castro, Elena
Kote-Jarai, Zsofia
Aprikian, Armen
Blanco Guillermo, Ignacio
Clowes, Virginia
Domchek, Susan M.
Douglas, Fiona
Eccles, Diana
Evans, D. Gareth
Harris, Marion
Kirk, Judy
Lam, Jimmy
Lindeman, Geoffrey J.
Mitchell, Gillian
Pachter, Nicholas
Selkirk, Christina
Tucker, Kathy
Zgajnar, Janaz
Eeles, Rosalind A.
Pandha, Hardev
Keywords: Càncer de pròstata
Factors de risc en les malalties
Marcadors tumorals
Antigen específic de la pròstata
Prostate cancer
Risk factors in diseases
Tumor markers
Prostate-specific antigen
Issue Date: 24-Jun-2013
Publisher: Nature Publishing Group
Abstract: Controversy surrounds the use of PSA as a biomarker for prostate cancer detection, leaving an unmet need for a novel biomarker in this setting; urinary EN2 may identify individuals with clinically relevant prostate cancer. Male BRCA1 and BRCA2 mutation carriers are at increased risk of clinically significant prostate cancer and may benefit from screening. Urine samples from 413 BRCA1 and BRCA2 mutation carriers and controls were evaluated. Subjects underwent annual PSA screening with diagnostic biopsy triggered by PSA > 3.0 ng/ml; 21 men were diagnosed with prostate cancer. Urinary EN2 levels were measured by ELISA and had a sensitivity of 66.7% and specificity of 89.3% for cancer detection. There was no statistically significant difference in EN2 levels according to genetic status or Gleason score. Urinary EN2 may be useful as a non-invasive early biomarker for prostate cancer detection in genetically high-risk individuals.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2013, vol. 3, p. 2059
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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