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http://hdl.handle.net/2445/100209
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DC Field | Value | Language |
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dc.contributor.author | Lloberas Cavero, Jorge | - |
dc.contributor.author | Valverde Estrella, Lorena | - |
dc.contributor.author | Tur Torres, Juan | - |
dc.contributor.author | Vico Rivero, Tania | - |
dc.contributor.author | Celada Cotarelo, Antonio | - |
dc.date.accessioned | 2016-07-07T11:28:45Z | - |
dc.date.available | 2016-07-07T11:28:45Z | - |
dc.date.issued | 2016-06-28 | - |
dc.identifier.uri | http://hdl.handle.net/2445/100209 | - |
dc.description.abstract | Macrophages are necessary in multiple processes during the immune response or inflammation. This review emphasizes the critical role of the mitogen-activated protein kinases (MAPKs) and mitogen kinase phosphatase-1 (MKP-1) in the functional activities of macrophages. While the phosphorylation of MAPKs is required for macrophage activation or proliferation, MKP-1 dephosphorylates these kinases, thus playing a balancing role in the control of macrophage behavior. MKP-1 is a nuclear-localized dual-specificity phosphatase whose expression is regulated at multiple levels, including at the transcriptional and post-transcriptional level. The regulatory role of MKP-1 in the interplay between MAPK phosphorylation/dephosphorylation makes this molecule a critical regulator of macrophage biology and inflammation. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.3389/fmolb.2016.00028 | - |
dc.relation.ispartof | Frontiers in Immunology, 2016, vol. 3, p. 1-8 | - |
dc.relation.uri | http://dx.doi.org/10.3389/fmolb.2016.00028 | - |
dc.rights | cc-by (c) Lloberas et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) | - |
dc.subject.classification | Enzims | - |
dc.subject.classification | Macròfags | - |
dc.subject.classification | Esterases | - |
dc.subject.other | Enzymes | - |
dc.subject.other | Macrophages | - |
dc.subject.other | Esterases | - |
dc.title | Mitogen-activated protein kinases and mitogen kinase phosphatase 1: a critical interplay in macrophage biology | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 662958 | - |
dc.date.updated | 2016-07-07T11:28:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27446931 | - |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
Files in This Item:
File | Description | Size | Format | |
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662958.pdf | 1.13 MB | Adobe PDF | View/Open |
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