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Title: HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels
Author: López-Dupla, Miguel
Maymó-Masip, Elsa
Martínez Chamorro, Esteban José
Domingo, Pere (Domingo Pedrol)
Leal, Manuel
Peraire, Joaquim
Viladés, Consuelo
Veloso, Sergio
Arnedo, Mireia
Ferrando-Martínez, Sara
Beltrán-Debón, Raúl
Alba, Verónica
Gatell, José M.
Vendrell, Joan
Vidal, Francesc
Chacón, Matilde R.
Keywords: Síndrome de lipodistròfia associada a VIH
VIH (Virus)
Estudi de casos
HIV-associated lipodystrophy syndrome
HIV (Viruses)
Antiretroviral agents
Case studies
Issue Date: 14-Dec-2015
Publisher: Public Library of Science (PLoS)
Abstract: Background and Objectives Obesity and HIV-1/HAART-associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. We sought to explore the relationship between HALS and circulating levels of soluble (s) TWEAK and its scavenger receptor sCD163. Methods This was a cross-sectional multicenter study of 120 HIV-1-infected patients treated with a stable HAART regimen; 56 with overt HALS and 64 without HALS. Epidemiological and clinical variables were determined. Serum levels of sTWEAK and sCD163 levels were measured by ELISA. Results were analyzed with Student's t-test, Mann-Whitney U and χ2 test. Pearson and Spearman correlation were used to estimate the strength of association between variables. Results Circulating sTWEAK was significantly decreased in HALS patients compared with non-HALS patients (2.81±0.2 vs. 2.94±0.28 pg/mL, p = 0.018). No changes were observed in sCD163 levels in the studied cohorts. On multivariate analysis, a lower log sTWEAK concentration was independently associated with the presence of HALS (OR 0.027, 95% CI 0.001-0.521, p = 0.027). Conclusions HALS is associated with decreased sTWEAK levels.
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It is part of: PLoS One, 2015, vol. 10, num. 12
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)

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