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DC Field | Value | Language |
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dc.contributor.author | Gattarello, Simone | - |
dc.contributor.author | Lagunes, Leonel | - |
dc.contributor.author | Vidaur, Loreto | - |
dc.contributor.author | Solé Violán, Jordi | - |
dc.contributor.author | Zaragoza, Rafael | - |
dc.contributor.author | Vallés, Jordi | - |
dc.contributor.author | Torres Martí, Antoni | - |
dc.contributor.author | Sierra, Rafael | - |
dc.contributor.author | Sebastian, Rosa | - |
dc.contributor.author | Rello Condomines, Jordi | - |
dc.date.accessioned | 2016-07-12T07:54:09Z | - |
dc.date.available | 2016-07-12T07:54:09Z | - |
dc.date.issued | 2015-09-10 | - |
dc.identifier.issn | 1364-8535 | - |
dc.identifier.uri | http://hdl.handle.net/2445/100405 | - |
dc.description.abstract | INTRODUCTION: We aimed to compare intensive care unit mortality due to non-pneumococcal severe community-acquired pneumonia between the periods 2000-2002 and 2008-2014, and the impact of the improvement in antibiotic strategies on outcomes. METHODS: This was a matched case-control study enrolling 144 patients with non-pneumococcal severe pneumonia: 72 patients from the 2000-2002 database (CAPUCI I group) were paired with 72 from the 2008-2014 period (CAPUCI II group), matched by the following variables: microorganism, shock at admission, invasive mechanical ventilation, immunocompromise, chronic obstructive pulmonary disease, and age over 65 years. RESULTS: The most frequent microorganism was methicillin-susceptible Staphylococcus aureus (22.1%) followed by Legionella pneumophila and Haemophilus influenzae (each 20.7%); prevalence of shock was 59.7%, while 73.6% of patients needed invasive mechanical ventilation. Intensive care unit mortality was significantly lower in the CAPUCI II group (34.7% versus 16.7%; odds ratio (OR) 0.78, 95% confidence interval (CI) 0.64-0.95; p = 0.02). Appropriate therapy according to microorganism was 91.5% in CAPUCI I and 92.7% in CAPUCI II, while combined therapy and early antibiotic treatment were significantly higher in CAPUCI II (76.4 versus 90.3% and 37.5 versus 63.9%; p < 0.05). In the multivariate analysis, combined antibiotic therapy (OR 0.23, 95% CI 0.07-0.74) and early antibiotic treatment (OR 0.07, 95% CI 0.02-0.22) were independently associated with decreased intensive care unit mortality. CONCLUSIONS: In non-pneumococcal severe community-acquired pneumonia , early antibiotic administration and use of combined antibiotic therapy were both associated with increased intensive care unit survival during the study period. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1186/s13054-015-1051-1 | - |
dc.relation.ispartof | Critical Care, 2015, vol. 19, p. 335 | - |
dc.relation.uri | http://dx.doi.org/10.1186/s13054-015-1051-1 | - |
dc.rights | cc-by (c) Gattarello, S. et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Pneumònia | - |
dc.subject.classification | Antibiòtics | - |
dc.subject.classification | Unitats de cures intensives | - |
dc.subject.classification | Estudi de casos | - |
dc.subject.other | Pneumonia | - |
dc.subject.other | Antibiotics | - |
dc.subject.other | Intensive care units | - |
dc.subject.other | Case studies | - |
dc.title | Improvement of antibiotic therapy and ICU survival in severe non-pneumococcal community-acquired pneumonia: a matched case-control study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 659707 | - |
dc.date.updated | 2016-07-12T07:54:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26369551 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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659707.pdf | 1 MB | Adobe PDF | View/Open |
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