Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/100421
Title: Cardiometabolic Risk Profiles in Patients With Impaired Fasting Glucose and/or Hemoglobin A1c 5.7% to 6.4%: Evidence for a Gradient According to Diagnostic Criteria. The PREDAPS Study
Author: Giráldez García, Carolina
Sangrós, F.J.
Díaz Redondo, Alicia
Franch Nadal, Josep
Serrano, Rosario
Díez, Javier
Buil Cosiales, P.
García Soidán, Francisco Javier
Artola, Sara
Ezkurra, Patxi
Carrillo, Lourdes
Millaruelo Trillo, José M.
Seguí, Mateu
Martínez Candela, Juan
Muñoz, Pedro
Goday Arnó, Albert
Regidor, Enrique
Keywords: Glucèmia
Malalties cardiovasculars
Factors de risc en les malalties
Estudi de casos
Blood sugar
Cardiovascular diseases
Risk factors in diseases
Case studies
Issue Date: 8-Oct-2015
Publisher: Lippincott, Williams & Wilkins. Wolters Kluwer Health
Abstract: It has been suggested that the early detection of individuals with prediabetes can help prevent cardiovascular diseases. The purpose of the current study was to examine the cardiometabolic risk profile in patients with prediabetes according to fasting plasma glucose (FPG) and/or hemoglobin A1c (HbA1c) criteria. Cross-sectional analysis from the 2022 patients in the Cohort study in Primary Health Care on the Evolution of Patients with Prediabetes (PREDAPS Study) was developed. Four glycemic status groups were defined based on American Diabetes Association criteria. Information about cardiovascular risk factors-body mass index, waist circumference, blood pressure, cholesterol, triglycerides, uric acid, gamma-glutamyltransferase, glomerular filtration-and metabolic syndrome components were analyzed. Mean values of clinical and biochemical characteristics and frequencies of metabolic syndrome were estimated adjusting by age, sex, educational level, and family history of diabetes. A linear trend (P < 0.001) was observed in most of the cardiovascular risk factors and in all components of metabolic syndrome. Normoglycemic individuals had the best values, individuals with both criteria of prediabetes had the worst, and individuals with only one-HbA1c or FPG-criterion had an intermediate position. Metabolic syndrome was present in 15.0% (95% confidence interval: 12.6-17.4), 59.5% (54.0-64.9), 62.0% (56.0-68.0), and 76.2% (72.8-79.6) of individuals classified in normoglycemia, isolated HbA1c, isolated FPG, and both criteria groups, respectively. In conclusion, individuals with prediabetes, especially those with both criteria, have worse cardiometabolic risk profile than normoglycemic individuals. These results suggest the need to use both criteria in the clinical practice to identify those individuals with the highest cardiovascular risk, in order to offer them special attention with intensive lifestyle intervention programs.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1097/MD.0000000000001935
It is part of: Medicine, 2015, vol. 94, num. 44, p. e1935
Related resource: http://dx.doi.org/10.1097/MD.0000000000001935
URI: http://hdl.handle.net/2445/100421
ISSN: 0025-7974
Appears in Collections:Articles publicats en revistes (Medicina)

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