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Title: Fructose, but not glucose, impairs insulin signaling in the three major insulin-sensitive tissues
Author: Baena Muñoz, Miguel
Sangüesa Puigventós, Gemma
Dávalos, Alberto
Latasa, Maria-Jesús
Sala Vila, Aleix
Sánchez Peñarroya, Rosa M.
Roglans i Ribas, Núria
Laguna Egea, Juan Carlos
Alegret i Jordà, Marta
Keywords: Diabetis
Resistència a la insulina
Experimentació animal
Insulin resistance
Animal experimentation
Issue Date: 19-May-2016
Publisher: Nature Publishing Group
Abstract: Human studies support the relationship between high intake of fructose-sweetened beverages and type 2 diabetes, but there is a debate on whether this effect is fructose-specific or it is merely associated to an excessive caloric intake. Here we investigate the effects of 2 months' supplementation to female rats of equicaloric 10% w/v fructose or glucose solutions on insulin sensitivity in target tissues. Fructose supplementation caused hepatic deposition of triglycerides and changed the fatty acid profile of this fraction, with an increase in monounsaturated and a decrease in polyunsaturated species, but did not cause inflammation and oxidative stress. Fructose but not glucose-supplemented rats displayed an abnormal glucose tolerance test, and did not show increased phosphorylation of V-akt murine thymoma viral oncogene homolog-2 (Akt) in white adipose tissue and liver after insulin administration. In skeletal muscle, phosphorylation of Akt and of Akt substrate of 160 kDA (AS160) was not impaired but the expression of the glucose transporter type 4 (GLUT4) in the plasma membrane was reduced only in fructose-fed rats. In conclusion, fructose but not glucose supplementation causes fatty liver without inflammation and oxidative stress and impairs insulin signaling in the three major insulin-responsive tissues independently from the increase in energy intake.
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It is part of: Scientific Reports, 2016, vol. 6, num. 26149
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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