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Title: | No major host genetic risk factor contributed to A(H1N1)2009 influenza severity |
Author: | Garcia-Etxebarria, Koldo Bracho, María Alma Galán, Juan Carlos Pumarola Suñé, Tomàs Castilla, Jesús Ortiz de Lejarazu, Raul Rodríguez-Dominguez, Mario Quintela, Inés Bonet, Núria Garcia-Garcerà, Marc Domínguez García, Àngela González-Candelas, Fernando Calafell, Francesc |
Keywords: | Grip Genòmica Factors de risc en les malalties Estudi de casos Influenza Genomics Risk factors in diseases Case studies |
Issue Date: | 17-Sep-2015 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | While most patients affected by the influenza A(H1N1) pandemic experienced mild symptoms, a small fraction required hospitalization, often without concomitant factors that could explain such a severe course. We hypothesize that host genetic factors could contribute to aggravate the disease. To test this hypothesis, we compared the allele frequencies of 547,296 genome-wide single nucleotide polymorphisms (SNPs) between 49 severe and 107 mild confirmed influenza A cases, as well as against a general population sample of 549 individuals. When comparing severe vs. mild influenza A cases, only one SNP was close to the conventional p = 5×10−8. This SNP, rs28454025, sits in an intron of the GSK233 gene, which is involved in a neural development, but seems not to have any connections with immunological or inflammatory functions. Indirectly, a previous association reported with CD55 was replicated. Although sample sizes are low, we show that the statistical power in our design was sufficient to detect highly-penetrant, quasi-Mendelian genetic factors. Hence, and assuming that rs28454025 is likely to be a false positive, no major genetic factor was detected that could explain poor influenza A course. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0135983 |
It is part of: | PLoS One, 2015, vol. 10, num. 9, p. e0135983 |
URI: | http://hdl.handle.net/2445/100545 |
Related resource: | http://dx.doi.org/10.1371/journal.pone.0135983 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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