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Title: No major host genetic risk factor contributed to A(H1N1)2009 influenza severity
Author: Garcia-Etxebarria, Koldo
Bracho, María Alma
Galán, Juan Carlos
Pumarola, Tomás
Castilla, Jesús
Ortiz de Lejarazu, Raul
Rodríguez-Dominguez, Mario
Quintela, Inés
Bonet, Núria
Garcia-Garcerà, Marc
Domínguez García, Àngela
González-Candelas, Fernando
Calafell, Francesc
Keywords: Grip
Factors de risc en les malalties
Estudi de casos
Risk factors in diseases
Case studies
Issue Date: 17-Sep-2015
Publisher: Public Library of Science (PLoS)
Abstract: While most patients affected by the influenza A(H1N1) pandemic experienced mild symptoms, a small fraction required hospitalization, often without concomitant factors that could explain such a severe course. We hypothesize that host genetic factors could contribute to aggravate the disease. To test this hypothesis, we compared the allele frequencies of 547,296 genome-wide single nucleotide polymorphisms (SNPs) between 49 severe and 107 mild confirmed influenza A cases, as well as against a general population sample of 549 individuals. When comparing severe vs. mild influenza A cases, only one SNP was close to the conventional p = 5×10−8. This SNP, rs28454025, sits in an intron of the GSK233 gene, which is involved in a neural development, but seems not to have any connections with immunological or inflammatory functions. Indirectly, a previous association reported with CD55 was replicated. Although sample sizes are low, we show that the statistical power in our design was sufficient to detect highly-penetrant, quasi-Mendelian genetic factors. Hence, and assuming that rs28454025 is likely to be a false positive, no major genetic factor was detected that could explain poor influenza A course.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2015, vol. 10, num. 9, p. e0135983
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)

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