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Title: Using the Electronic Nose to Identify Airway Infection During COPD Exacerbations
Author: Shafiek, Hanaa
Fiorentino, Federico
Merino, Jose Luis
López, Carla
Oliver, Antonio
Segura, Jaume
Paul, Ivan de
Sibila Vidal, Oriol
Agustí García-Navarro, Àlvar
Cosío, Borja G.
Keywords: Malalties pulmonars obstructives cròniques
Compostos orgànics volàtils
Estudi de casos
Chronic obstructive pulmonary diseases
Volatile organic compounds
Case studies
Issue Date: 9-Sep-2015
Publisher: Public Library of Science (PLoS)
Abstract: Background The electronic nose (e-nose) detects volatile organic compounds (VOCs) in exhaled air. We hypothesized that the exhaled VOCs print is different in stable vs. exacerbated patients with chronic obstructive pulmonary disease (COPD), particularly if the latter is associated with airway bacterial infection, and that the e-nose can distinguish them. Methods Smell-prints of the bacteria most commonly involved in exacerbations of COPD (ECOPD) were identified in vitro. Subsequently, we tested our hypothesis in 93 patients with ECOPD, 19 of them with pneumonia, 50 with stable COPD and 30 healthy controls in a cross-sectional case-controlled study. Secondly, ECOPD patients were re-studied after 2 months if clinically stable. Exhaled air was collected within a Tedlar bag and processed by a Cynarose 320 e-nose. Breath-prints were analyzed by Linear Discriminant Analysis (LDA) with "One Out" technique and Sensor logic Relations (SLR). Sputum samples were collected for culture. Results ECOPD with evidence of infection were significantly distinguishable from non-infected ECOPD (p = 0.018), with better accuracy when ECOPD was associated to pneumonia. The same patients with ECOPD were significantly distinguishable from stable COPD during follow-up (p = 0.018), unless the patient was colonized. Additionally, breath-prints from COPD patients were significantly distinguished from healthy controls. Various bacteria species were identified in culture but the e-nose was unable to identify accurately the bacteria smell-print in infected patients. Conclusion E-nose can identify ECOPD, especially if associated with airway bacterial infection or pneumonia.
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It is part of: PLoS One, 2015, vol. 10, num. 9, p. e0135199
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)

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