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Title: Hypoxaemia in Mozambican children < 5 years of age admitted to hospital with clinical severe pneumonia: clinical features and performance of predictor models
Author: Bassat Orellana, Quique
Lanaspa, Miguel
Machevo, Sonia
O'Callaghan Gordo, Cristina
Madrid, Lola
Nhampossa, Tacilta
Acácio, Sozinho
Roca, A.
Alonso, Pedro
Keywords: Infants
Issue Date: 11-Jul-2016
Publisher: Wiley Online Library
Abstract: OBJECTIVE: To determine the prevalence of hypoxaemia among under-five children admitted to hospital with clinical severe pneumonia, and to assess the performance to diagnose hypoxaemia of models based on clinical signs. METHODS: We conducted a hospital-based survey in a district hospital from Southern Mozambique. RESULTS: A total of 825 children were recruited after obtaining an informed consent. The prevalence of hypoxaemia on admission was 27.9%, and 19.8% of these children died (OR compared to non-hypoxaemic children 3.22, 95%CI 1.98 - 5.21, p<0.001). The model with larger area under the ROC curve (AUC-ROC) to predict hypoxaemia included cyanosis or thoracoabdominal breathing or respiratory rate >/= 70 breaths per minute. None of the models performed well when tested in different case scenarios of oxygen availability through mathematical modelling, with over 50% of hypoxaemic children not receiving oxygen even in favourable case scenarios. CONCLUSIONS: Clinical signs alone or in combination are not suitable to diagnose hypoxaemia. The use of pulse oximeters should be strongly encouraged. This article is protected by copyright. All rights reserved.
Note: Versió postprint del document publicat a:
It is part of: Tropical Medicine & International Health, 2016
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ISSN: 1360-2276
Appears in Collections:Articles publicats en revistes (ISGlobal)

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