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Title: Young adolescent girls are at high risk for adverse pregnancy outcomes in sub-Saharan Africa: an observational multicountry study
Author: Mombo-Ngoma, Ghyslain
Mackanga, Jean Rodolphe
González, Raquel
Ouédraogo, Smaila
Kakolwa, Mwaka A.
Zoleko-Manego, Rella
Basra, Arti
Rupérez, María
Cot, Michel
Kabanywanyi, Abdunoor M.
Matsiegui, Pierre-Blaise
Agnandji, Selidji Todagbe
Vala, Anifa
Massougbodji, Achille
Abdulla, Salim
Adegnika, Ayôla A.
Sevene, Esperança Júlia Pires
Macete, Eusebio Víctor
Yazdanbakhsh, Maria
Kremsner, Peter G.
Aponte, John J.
Menéndez, Clara
Ramharter, Michael
Keywords: Adolescents
Àfrica subsahariana
Sub-Saharan Africa
Issue Date: 29-Jun-2016
Publisher: BMJ Journals
Abstract: Objectives: One of Africa's most important challenges is to improve maternal and neonatal health. The identification of groups at highest risk for adverse pregnancy outcomes is important for developing and implementing targeted prevention programmes. This study assessed whether young adolescent girls constitute a group at increased risk for adverse birth outcomes among pregnant women in sub-Saharan Africa. Setting: Data were collected prospectively as part of a large randomised controlled clinical trial evaluating intermittent preventive treatment of malaria in pregnancy (NCT00811421—Clinical, conducted between September 2009 and December 2013 in Benin, Gabon, Mozambique and Tanzania. Participants: Of 4749 participants, pregnancy outcomes were collected for 4388 deliveries with 4183 live births including 83 multiple gestations. Of 4100 mothers with a singleton live birth delivery, 24% (975/4100) were adolescents (≤19 years of age) and 6% (248/4100) were aged ≤16 years. Primary and secondary outcome measures: Primary outcomes of this predefined analysis were preterm delivery and low birth weight. Results: The overall prevalence of low birthweight infants and preterm delivery was 10% (371/3851) and 4% (159/3862), respectively. Mothers aged ≤16 years showed higher risk for the delivery of a low birthweight infant (OR: 1.96; 95% CI 1.35 to 2.83). Similarly, preterm delivery was associated with young maternal age (≤16 years; OR: 2.62; 95% CI 1.59 to 4.30). In a subanalysis restricted to primiparous women: preterm delivery, OR 4.28; 95% CI 2.05 to 8.93; low birth weight, OR: 1.29; 95% CI 0.82 to 2.01. Conclusions: Young maternal age increases the risk for adverse pregnancy outcomes and it is a stronger predictor for low birth weight and preterm delivery than other established risk factors in sub-Saharan Africa. This finding highlights the need to improve adolescent reproductive health in sub-Saharan Africa.
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It is part of: BMJ Open, 2016, vol. 6, num. 6, p. e011783
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ISSN: 2044-6055
Appears in Collections:Articles publicats en revistes (ISGlobal)

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