Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/100940
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Noriega, Victor | - |
dc.contributor.author | Martínez-Laperche, Carolina | - |
dc.contributor.author | Buces, Elena | - |
dc.contributor.author | Pion, Marjorie | - |
dc.contributor.author | Sánchez-Hernández, Noemí | - |
dc.contributor.author | Martín-Antonio, Beatriz | - |
dc.contributor.author | Guillem, Vicent | - |
dc.contributor.author | Bosch-Vizcaya, Anna | - |
dc.contributor.author | Bento, Leyre | - |
dc.contributor.author | González Rivera, Milagros | - |
dc.contributor.author | Balsalobre, Pascual | - |
dc.contributor.author | Kwon, Mi | - |
dc.contributor.author | Serrano, David | - |
dc.contributor.author | Gayoso, Jorge | - |
dc.contributor.author | Cámara, Rafael de la | - |
dc.contributor.author | Brunet, Salut | - |
dc.contributor.author | Rojas-Contreras, Rafael | - |
dc.contributor.author | Nieto, José B. | - |
dc.contributor.author | Martínez, Carmen | - |
dc.contributor.author | Gónzalez, Marcos | - |
dc.contributor.author | Espigado, Ildefonso | - |
dc.contributor.author | Vallejo, Carlos | - |
dc.contributor.author | Sampol, Antonia | - |
dc.contributor.author | Jiménez-Velasco, Antonio | - |
dc.contributor.author | Urbano Ispizua, Álvaro | - |
dc.contributor.author | Solano, Carlos | - |
dc.contributor.author | Gallardo, David | - |
dc.contributor.author | Díez-Martín, José L. | - |
dc.contributor.author | Buño, Ismael | - |
dc.contributor.author | Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH) | - |
dc.date.accessioned | 2016-07-25T17:22:07Z | - |
dc.date.available | 2016-07-25T17:22:07Z | - |
dc.date.issued | 2015-10-16 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/100940 | - |
dc.description.abstract | The FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft versus host disease while probably maintaining a graft versus leukemia effect. Short alleles (≤(GT)15) for the (GT)n polymorphism in the promoter/enhancer of FOXP3 are associated with a higher expression of FOXP3, and hypothetically with an increase of regulatory T cell activity. This polymorphism has been related to the development of auto- or alloimmune conditions including type 1 diabetes or graft rejection in renal transplant recipients. However, its impact in the allo-transplant setting has not been analyzed. In the present study, which includes 252 myeloablative HLA-identical allo-transplants, multivariate analysis revealed a lower incidence of grade III-IV acute graft versus host disease (GVHD) in patients transplanted from donors harboring short alleles (OR = 0.26, CI 0.08-0.82, p = 0.021); without affecting chronic GVHD or graft versus leukemia effect, since cumulative incidence of relapse, event free survival and overall survival rates are similar in both groups of patients. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0140454 | - |
dc.relation.ispartof | PLoS One, 2015, vol. 10, num. 10 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0140454 | - |
dc.rights | cc-by (c) Noriega et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Limfòcits | - |
dc.subject.classification | Cèl·lules T | - |
dc.subject.classification | Cèl·lules mare | - |
dc.subject.other | Lymphocytes | - |
dc.subject.other | T cells | - |
dc.subject.other | Stem cells | - |
dc.title | The Genotype of the Donor for the (GT)n Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 659974 | - |
dc.date.updated | 2016-07-25T17:22:12Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26473355 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
659974.pdf | 881.76 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License