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Title: Characterization of Vaginal Escherichia coli Isolated from Pregnant Women in Two Different African Sites
Author: Sáez-López, Emma
Cossa, Anelsio
Benmessaoud, Rachid
Madrid, Lola
Moraleda Redecilla, Cinta
Villanueva, Sonia
Tligui, Houssain
Moiane, Benilde
Alami, Hassan
Massora, Sérgio
Bezad, Rachid
Mandomando, Inácio
Bosch Mestres, Jordi
Vila Estapé, Jordi
Bassat Orellana, Quique
Soto, Sara M. (Sara Maria)
Keywords: Escheríchia coli
Resistència als medicaments
Escherichia coli
Pregnant women
Drug resistance
Issue Date: 7-Jul-2016
Publisher: Public Library of Science (PLoS)
Abstract: The relevance of vaginal colonization of pregnant women by Escherichia coli is poorly understood, despite these strains sharing a similar virulence profile with other extraintestinal pathogenic E. coli producing severe obstetric and neonatal infections. We characterized the epidemiology, antimicrobial susceptibility and virulence profiles of 84 vaginal E. coli isolates from pregnant women from Rabat (Morocco) and Manhica (Mozambique), two very distinct epidemiological settings. Low levels of antimicrobial resistance were observed to all drugs tested, except for trimethoprim-sulfamethoxazole in Manhica, where this drug is extensively used as prophylaxis for opportunistic HIV infections. The most prevalent virulence factors were related to iron acquisition systems. Phylogroup A was the most common in Rabat, while phylogroups E and non-typeable were the most frequent in Manhica. Regardless of the apparently "low virulence" of these isolates, the frequency of infections is higher and the outcomes more devastating in constrained-resources conditions, especially among pregnant women and newborns.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2016, vol. 11, num. 7, p. e0158695
Related resource:
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Fonaments Clínics)

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