Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/101564
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gruzieva, Olena | - |
dc.contributor.author | Xu, Cheng-Jian | - |
dc.contributor.author | Breton, Carrie V. | - |
dc.contributor.author | Annesi-Maesano, Isabella | - |
dc.contributor.author | Antó i Boqué, Josep Maria | - |
dc.contributor.author | Auffray, Charles | - |
dc.contributor.author | Ballereau, Stephane | - |
dc.contributor.author | Bellander, Tom | - |
dc.contributor.author | Bousquet, Jean | - |
dc.contributor.author | Bustamante Pineda, Mariona | - |
dc.contributor.author | Charles, Marie-Aline | - |
dc.contributor.author | Kluizenaar, Yvonne de | - |
dc.contributor.author | Dekker, Herman T. den | - |
dc.contributor.author | Duijts, Liesbeth | - |
dc.contributor.author | Felix, Janine F. | - |
dc.contributor.author | Gehring, Ulrike | - |
dc.contributor.author | Guxens, Mònica | - |
dc.contributor.author | Jaddoe, Vincent W. | - |
dc.contributor.author | Jankipersadsing, Soesma A. | - |
dc.contributor.author | Merid, Simon Kebede | - |
dc.contributor.author | Kere, Juha | - |
dc.contributor.author | Kumar, Ashish | - |
dc.contributor.author | Lemonnier, Nathanael | - |
dc.contributor.author | Lepeule, Johanna | - |
dc.contributor.author | Nystad, Wenche | - |
dc.contributor.author | Page, Christian Magnus | - |
dc.contributor.author | Panasevich, Sviatlana | - |
dc.contributor.author | Postma, Dirkje S. | - |
dc.contributor.author | Slama, Rémy | - |
dc.contributor.author | Sunyer Deu, Jordi | - |
dc.contributor.author | Soderhall, Cilla | - |
dc.contributor.author | Yao, Jin | - |
dc.contributor.author | London, Stephanie J. | - |
dc.contributor.author | Pershagen, Göran | - |
dc.contributor.author | Koppelman, Gerard H. | - |
dc.contributor.author | Melén, Erik | - |
dc.date.accessioned | 2016-09-06T06:43:34Z | - |
dc.date.available | 2016-09-06T06:43:34Z | - |
dc.date.issued | 2016-07-22 | - |
dc.identifier.issn | 0091-6765 | - |
dc.identifier.uri | http://hdl.handle.net/2445/101564 | - |
dc.description.abstract | BACKGROUND: Prenatal exposure to air pollution is considered to be associated with adverse effects on child health. This may partly be mediated by mechanisms related to DNA methylation. OBJECTIVES: We investigated associations between exposure to air pollution, using nitrogen dioxide (NO2) as marker, and epigenome-wide cord blood DNA methylation. METHODS: We meta-analyzed the associations between NO2 exposure at residential addresses during pregnancy and cord blood DNA methylation (Illumina 450K) in four European and North-American studies (n=1,508) with subsequent look-up analyses in children aged 4 (n=733) and 8 (n=786) years. Additionally, we applied a literature-based candidate approach for antioxidant and anti-inflammatory genes. To assess influence of exposure at the transcriptomics level, we related mRNA expression in blood cells to NO2 exposure in 4- (n=111) and 16-year-olds (n=239). RESULTS: We found epigenome-wide significant associations (false discovery rate (FDR) p<0.05) between maternal NO2 exposure during pregnancy and DNA methylation in newborns for 3 CpG sites in mitochondria-related genes: cg12283362 (LONP1), cg24172570 (3.8 kbp upstream of HIBADH), and cg08973675 (SLC25A28). The associations with cg08973675 methylation were also significant in the older children. Further analysis of antioxidant and anti-inflammatory genes revealed differentially methylated CpGs in CAT and TPO in newborns (FDR p<0.05). NO2 exposure at the time of biosampling in childhood had significant impact on CAT and TPO expression. CONCLUSIONS: NO2 exposure during pregnancy was associated with differential offspring DNA methylation in mitochondria-related genes. Exposure to NO2 was also linked to differential methylation as well as expression of genes involved in antioxidant defense pathways. | - |
dc.format.extent | 30 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | National Institute of Environmental Health Sciences | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1289/EHP36 | - |
dc.relation.ispartof | Environmental Health Perspectives, 2016 | - |
dc.relation.uri | http://dx.doi.org/10.1289/EHP36 | - |
dc.rights | Domini públic / Public domain | - |
dc.rights.uri | http://creativecommons.org/publicdomain/mark/1.0/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Contaminació | - |
dc.subject.classification | Medicina prenatal | - |
dc.subject.other | Pollution | - |
dc.subject.other | Prenatal medicine | - |
dc.title | Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2016-08-10T18:00:37Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/648916/EU//EMBRYOandLATERHEALTH | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/633595/EU//DYNAHEALTH | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27448387 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
gruzieva2016_2203.pdf | 424.42 kB | Adobe PDF | View/Open |
This item is in the public domain