Please use this identifier to cite or link to this item:
Title: Variation in relapse frequency and the transmission potential of Plasmodium vivax malaria
Author: White, M. T.
Shirreff, G.
Karl, S.
Ghani, A. C.
Mueller, Ivo
Keywords: Plasmodium vivax
Models matemàtics
Plasmodium vivax
Mathematical models
Mathematical models
Issue Date: 30-Mar-2016
Publisher: Royal Society
Abstract: There is substantial variation in the relapse frequency of Plasmodium vivax malaria, with fast-relapsing strains in tropical areas, and slow-relapsing strains in temperate areas with seasonal transmission. We hypothesize that much of the phenotypic diversity in P. vivax relapses arises from selection of relapse frequency to optimize transmission potential in a given environment, in a process similar to the virulence trade-off hypothesis. We develop mathematical models of P. vivax transmission and calculate the basic reproduction number R0 to investigate how transmission potential varies with relapse frequency and seasonality. In tropical zones with year-round transmission, transmission potential is optimized at intermediate relapse frequencies of two to three months: slower-relapsing strains increase the opportunity for onward transmission to mosquitoes, but also increase the risk of being outcompeted by faster-relapsing strains. Seasonality is an important driver of relapse frequency for temperate strains, with the time to first relapse predicted to be six to nine months, coinciding with the duration between seasonal transmission peaks. We predict that there is a threshold degree of seasonality, below which fast-relapsing tropical strains are selected for, and above which slow-relapsing temperate strains dominate, providing an explanation for the observed global distribution of relapse phenotypes.
Note: Reproducció del document publicat a:
It is part of: Proceedings. Biological Sciences, 2016, vol. 283, num. 1827, p. 20160048
Related resource:
ISSN: 0962-8452
Appears in Collections:Articles publicats en revistes (ISGlobal)

Files in This Item:
File Description SizeFormat 
white2016_2207.pdf1.09 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons