Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/101694
Title: Functionalized surfaces with tailored wettability determine Influenza A infectivity
Author: Mannelli, Ilaria
Reigada Sanz, Ramon
Suárez, Irina
Janner, Davide
Carrilero, Albert
Mazumder, Prantik
Sagués i Mestre, Francesc
Pruneri, Valerio
Lakadamyali, Melike
Keywords: Grip aviària
Superfícies hidrofòbiques
Microscòpia de fluorescència
Materials nanoestructurats
Dinàmica molecular
Avian influenza
Hydrophobic surfaces
Fluorescence microscopy
Nanostructured materials
Molecular dynamics
Issue Date: 31-May-2016
Publisher: American Chemical Society
Abstract: Surfaces contaminated with pathogenic microorganisms contribute to their transmission and spreading. The development of 'active surfaces' that can reduce or eliminate this contamination necessitates a detailed understanding of the molecular mechanisms of interactions between the surfaces and the microorganisms. Few studies have shown that, among the different surface characteristics, the wetting properties play an important role in reducing virus infectivity. Here, we systematically tailored the wetting characteristics of flat and nanostructured glass surfaces by functionalizing them with alkyl- and fluoro-silanes. We studied the effects of these functionalized surfaces on the infectivity of Influenza A viruses using a number of experimental and computational methods including real-time fluorescence microscopy and molecular dynamics simulations. Overall, we show that surfaces that are simultaneously hydrophobic and oleophilic are more efficient in deactivating enveloped viruses. Our results suggest that the deactivation mechanism likely involves disruption of the viral membrane upon its contact with the alkyl chains. Moreover, enhancing these specific wetting characteristics by surface nanostructuring led to an increased deactivation of viruses. These combined features make these substrates highly promising for applications in hospitals and similar infrastructures where antiviral surfaces can be crucial.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1021/acsami.6b02779
It is part of: ACS Applied Materials & Interfaces, 2016, vol. 8, num. 24, p. 15058-15066
Related resource: http://dx.doi.org/10.1021/acsami.6b02779
URI: http://hdl.handle.net/2445/101694
ISSN: 1944-8244
Appears in Collections:Articles publicats en revistes (Ciència dels Materials i Química Física)

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