Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/101708
Title: Magnetite-Amyloid-β deteriorates activity and functional organization in an in vitro model for Alzheimer's disease
Author: Teller, Sara
Tahirbegi, Islam Bogachan
Mir Llorente, Mònica
Samitier i Martí, Josep
Soriano i Fradera, Jordi
Keywords: Malaltia d'Alzheimer
Magnetita
Amiloïdosi
Alzheimer's disease
Magnetite
Amyloidosis
Issue Date: 26-Nov-2015
Publisher: Nature Publishing Group
Abstract: The understanding of the key mechanisms behind human brain deterioration in Alzheimer' disease (AD) is a highly active field of research. The most widespread hypothesis considers a cascade of events initiated by amyloid-β peptide fibrils that ultimately lead to the formation of the lethal amyloid plaques. Recent studies have shown that other agents, in particular magnetite, can also play a pivotal role. To shed light on the action of magnetite and amyloid-β in the deterioration of neuronal circuits, we investigated their capacity to alter spontaneous activity patterns in cultured neuronal networks. Using a versatile experimental platform that allows the parallel monitoring of several cultures, the activity in controls was compared with the one in cultures dosed with magnetite, amyloid-β and magnetite-amyloid-β complex. A prominent degradation in spontaneous activity was observed solely when amyloid-β and magnetite acted together. Our work suggests that magnetite nanoparticles have a more prominent role in AD than previously thought, and may bring new insights in the understanding of the damaging action of magnetite-amyloid-β complex. Our experimental system also offers new interesting perspectives to explore key biochemical players in neurological disorders through a controlled, model system manner.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1038/srep17261
It is part of: Scientific Reports, 2015, vol. 5, num. 17261
Related resource: http://dx.doi.org/10.1038/srep17261
URI: http://hdl.handle.net/2445/101708
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Física de la Matèria Condensada)

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