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http://hdl.handle.net/2445/102067
Title: | Efficient preparation of (S)- and (R)-tert-Butylmethylphosphine-Borane: a novel entry to important P-Stereogenic ligands |
Author: | Salomó i Prat, Ernest Orgué Gassol, Sílvia Riera i Escalé, Antoni Verdaguer i Espaulella, Xavier |
Keywords: | Compostos fosforosos Lligands (Bioquímica) Phosphorus compounds Ligands (Biochemistry) |
Issue Date: | 22-Mar-2016 |
Publisher: | Georg Thieme Verlag |
Abstract: | A novel one-pot reductive methodol. for the synthesis of optically pure tert-butylmethylphosphine-borane is reported. The prepn. uses as the starting material tert-butylmethylphosphinous acid-borane, which is available in both enantiomeric forms from cis-1,2-aminoindanol and tert-butyldichlorophosphine. The process is based on the redn. of a mixed anhydride, the configurational stability of which has been studied in several solvents and temps. Tetrabutylammonium borohydride was the best reducing agent allowing for the development of a practical process. To demonstrate the utility of the new methodol., the product obtained in this manner was used in the prepn. of Quinox-P*. |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1055/s-0035-1561854 |
It is part of: | Synthesis. Journal of Synthetic Organic Chemistry, 2016, vol. 48, num. 16, p. 2659-2663 |
URI: | http://hdl.handle.net/2445/102067 |
Related resource: | http://dx.doi.org/10.1055/s-0035-1561854 |
ISSN: | 0039-7881 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
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