Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/102067
Title: Efficient preparation of (S)- and (R)-tert-Butylmethylphosphine-Borane: a novel entry to important P-Stereogenic ligands
Author: Salomó, Ernest
Orgué Gassol, Sílvia
Riera i Escalé, Antoni
Verdaguer i Espaulella, Xavier
Keywords: Compostos fosforosos
Lligands (Bioquímica)
Phosphorus compounds
Ligands (Biochemistry)
Issue Date: 22-Mar-2016
Publisher: Georg Thieme Verlag
Abstract: A novel one-pot reductive methodol. for the synthesis of optically pure tert-butylmethylphosphine-borane is reported. The prepn. uses as the starting material tert-butylmethylphosphinous acid-borane, which is available in both enantiomeric forms from cis-1,2-aminoindanol and tert-butyldichlorophosphine. The process is based on the redn. of a mixed anhydride, the configurational stability of which has been studied in several solvents and temps. Tetrabutylammonium borohydride was the best reducing agent allowing for the development of a practical process. To demonstrate the utility of the new methodol., the product obtained in this manner was used in the prepn. of Quinox-P*.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1055/s-0035-1561854
It is part of: Synthesis. Journal of Synthetic Organic Chemistry, 2016, vol. 48, num. 16, p. 2659-2663
Related resource: http://dx.doi.org/10.1055/s-0035-1561854
URI: http://hdl.handle.net/2445/102067
ISSN: 0039-7881
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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