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Title: Electrospun materials as potential platforms for bone tissue engineering
Author: Jang, Jun-Hyeog
Castaño Linares, Óscar
Kim, Hae-Won
Keywords: Teixit ossi
Enginyeria de teixits
Tissue engineering
Issue Date: 29-Jul-2009
Publisher: Elsevier
Abstract: Nanofibrous materials produced by electrospinning processes have attracted considerable interest in tissue regeneration, including bone reconstruction. A range of novel materials and processing tools have been developed to mimic the native bone extracellular matrix for potential applications as tissue engineering scaffolds and ultimately to restore degenerated functions of the bone. Degradable polymers, bioactive inorganics and their nanocomposites/hybrids nanofibers with suitable mechanical properties and bone bioactivity for osteoblasts and progenitor/stem cells have been produced. The surface functionalization with apatite minerals and proteins/peptides as well as drug encapsulation within the nanofibers is a promising strategy for achieving therapeutic functions with nanofibrous materials. Recent attempts to endow a 3D scaffolding technique to the electrospinning regime have shown some promise for engineering 3D tissue constructs. With the improvement in knowledge and techniques of bone-targeted nanofibrous matrices, bone tissue engineering is expected to be realized in the near future.
Note: Versió postprint del document publicat a:
It is part of: Advanced Drug Delivery Reviews, 2009, vol. 61, num. 12, p. 1065-1083
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ISSN: 0169-409X
Appears in Collections:Articles publicats en revistes (Ciència dels Materials i Química Física)

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