Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/102342
Title: ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration
Author: Santabárbara Ruiz, Paula
López Santillán, Mireya
Martínez Rodríguez, Irene
Binagui Casas, Anahí
Pérez, Lidia
Milán, Marco
Corominas, Montserrat (Corominas Guiu)
Serras Rigalt, Florenci
Keywords: Apoptosi
Mort cel·lular
Larves
Regeneració (Biologia)
Antioxidants
Drosòfila melanogaster
Apoptosis
Cell death
Larvae
Regeneration (Biology)
Antioxidants
Drosophila melanogaster
Issue Date: 23-Oct-2015
Publisher: Public Library of Science (PLoS)
Abstract: Upon apoptotic stimuli, epithelial cells compensate the gaps left by dead cells by activating proliferation. This has led to the proposal that dying cells signal to surrounding living cells to maintain homeostasis. Although the nature of these signals is not clear, reactive oxygen species (ROS) could act as a signaling mechanism as they can trigger pro-inflammatory responses to protect epithelia from environmental insults. Whether ROS emerge from dead cells and what is the genetic response triggered by ROS is pivotal to understand regeneration of Drosophila imaginal discs. We genetically induced cell death in wing imaginal discs, monitored the production of ROS and analyzed the signals required for repair. We found that cell death generates a burst of ROS that propagate to the nearby surviving cells. Propagated ROS activate p38 and induce tolerable levels of JNK. The activation of JNK and p38 results in the expression of the cytokines Unpaired (Upd), which triggers the JAK/STAT signaling pathway required for regeneration. Our findings demonstrate that this ROS/JNK/p38/Upd stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pgen.1005595
It is part of: PLoS Genetics, 2015, vol. 11, num. 10
Related resource: http://dx.doi.org/10.1371/journal.pgen.1005595
URI: http://hdl.handle.net/2445/102342
ISSN: 1553-7390
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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