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Title: Towards 4th generation biomaterials: a covalent hybrid polymer-ormoglass architecture
Author: Sachot, Nadège
Mateos-Timoneda, M. A.
Planell, J. A. (Josep Anton)
Velders, A. H.
Lewandowska, Malgorzata
Engel, Elisabeth
Castaño Linares, Óscar
Keywords: Nanopartícules
Interacció cel·lular
Enginyeria de teixits
Cell interaction
Tissue engineering
Issue Date: 19-Aug-2015
Publisher: Royal Society of Chemistry
Abstract: Hybrid materials are being extensively investigated with the aim of mimicking the ECM microenvironment to develop effective solutions for bone tissue engineering. However, the common drawbacks of a hybrid material are the lack of interactions between the scaffold's constituents and the masking of its bioactive phase. Conventional hybrids often degrade in a non-homogeneous manner and the biological response is far from optimal. We have developed a novel material with strong interactions between constituents. The bioactive phase is directly exposed on its surface mimicking the structure of the ECM of bone. Here, polylactic acid electrospun fibers have been successfully and reproducibly coated with a bioactive organically modified glass (ormoglass, Si-Ca-P2 system) covalently. In comparison with the pure polymeric mats, the fibers obtained showed improved hydrophilicity and mechanical properties, bioactive ion release, exhibited a nanoroughness and enabled good cell adhesion and spreading after just one day of culture (rMSCs and rEPCs). The fibers were coated with different ormoglass compositions to tailor their surface properties (roughness, stiffness, and morphology) by modifying the experimental parameters. Knowing that cells modulate their behavior according to the exposed physical and chemical signals, the development of this instructive material is a valuable advance in the design of functional regenerative biomaterials.
Note: Reproducció del document publicat a:
It is part of: Nanoscale, 2015, vol. 37, num. 7, p. 15349-15361
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ISSN: 2040-3364
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Ciència dels Materials i Química Física)

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