Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/102452
Title: The association between naturally acquired IgG subclass specific antibodies to the PfRH5 invasion complex and protection from Plasmodium falciparum malaria
Author: Weaver, Rupert
Reiling, Linda
Feng, Gaoqian
Drew, Damien R.
Mueller, Ivo
Siba, Peter M.
Tsuboi, Takafum
Richards, Jack S.
Fowkes, Freya J. I.
Beeson, James G.
Keywords: Malària
Plasmodium falciparum
Sistema immunològic
Malaria
Plasmodium falciparum
Immune system
Issue Date: 8-Sep-2016
Publisher: Springer Nature
Abstract: Understanding the targets and mechanisms of human immunity to malaria is important for advancing the development of highly efficacious vaccines and serological tools for malaria surveillance. The PfRH5 and PfRipr proteins form a complex on the surface of P. falciparum merozoites that is essential for invasion of erythrocytes and are vaccine candidates. We determined IgG subclass responses to these proteins among malaria-exposed individuals in Papua New Guinea and their association with protection from malaria in a longitudinal cohort of children. Cytophilic subclasses, IgG1 and IgG3, were predominant with limited IgG2 and IgG4, and IgG subclass-specific responses were higher in older children and those with active infection. High IgG3 to PfRH5 and PfRipr were significantly and strongly associated with reduced risk of malaria after adjusting for potential confounding factors, whereas associations for IgG1 responses were generally weaker and not statistically significant. Results further indicated that malaria exposure leads to the co-acquisition of IgG1 and IgG3 to PfRH5 and PfRipr, as well as to other PfRH invasion ligands, PfRH2 and PfRH4. These findings suggest that IgG3 responses to PfRH5 and PfRipr may play a significant role in mediating naturally-acquired immunity and support their potential as vaccine candidates and their use as antibody biomarkers of immunity.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1038/srep33094
It is part of: Scientific Reports, 2016, vol. 6, num. 33094
Related resource: http://dx.doi.org/10.1038/srep33094
URI: http://hdl.handle.net/2445/102452
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (ISGlobal)

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