Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/102547
Title: Preclinical and clinical studies for sodium tungstate: application in humans.
Author: Bertinat, Romina
Nualart, Francisco
Li, Xuhang
Yáñez, Alejandro J
Gomis, Ramon, 1946-
Keywords: Wolframats
Diabetis
Insulina
Glucosa
Pes corporal
Gliconeogènesi
Tungstates
Diabetes
Insulin
Glucose
Body weight
Gluconeogenesis
Issue Date: 25-Feb-2015
Publisher: OMICS Publishing Group
Abstract: Diabetes is a complex metabolic disorder triggered by the deficient secretion of insulin by the pancreatic β-cell or the resistance of peripheral tissues to the action of the hormone. Chronic hyperglycemia is the major consequence of this failure, and also the main cause of diabetic problems. Indeed, several clinical trials have agreed in that tight glycemic control is the best way to stop progression of the disease. Many anti-diabetic drugs for treatment of type 2 diabetes are commercially available, but no ideal normoglycemic agent has been developed yet. Moreover, weight gain is the most common side effect of many oral anti-diabetic agents and insulin, and increased weight has been shown to worsen glycemic control and increase the risk of diabetes progression. In this sense, the inorganic salt sodium tungstate (NaW) has been studied in different animal models of metabolic syndrome and diabetes, proving to have a potent effect on normalizing blood glucose levels and reducing body weight, without any hypoglycemic action. Although the liver has been studied as the main site of NaW action, positive effects have been also addressed in muscle, pancreas, brain, adipose tissue and intestine, explaining the effective anti-diabetic action of this salt. Here, we review NaW research to date in these different target organs. We believe that NaW deserves more attention, since all available anti-diabetic treatments remain suboptimal and new therapeutics are urgently needed.
Note: Reproducció del document publicat a: http://dx.doi.org/10.4172/2155-9899.1000285
It is part of: Journal of Clinical and Cellular Immunology, 2015, vol. 6, num. 1, p. 285
Related resource: http://dx.doi.org/10.4172/2155-9899.1000285
URI: http://hdl.handle.net/2445/102547
ISSN: 2155-9899
Appears in Collections:Articles publicats en revistes (Medicina)

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