Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/102728
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCollado, Sílvia-
dc.contributor.authorColl Piera, Elisabeth-
dc.contributor.authorNicolau, Carlos-
dc.contributor.authorPons, Mercedes-
dc.contributor.authorCruzado, Josep Ma.-
dc.contributor.authorPascual, Julio (Pascual Santos)-
dc.contributor.authorCases Amenós, A. (Aleix)-
dc.date.accessioned2016-10-19T08:22:21Z-
dc.date.available2016-10-19T08:22:21Z-
dc.date.issued2015-06-01-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/2445/102728-
dc.description.abstractBackground To evaluate the predictive value of carotid atherosclerotic disease (CAD) and intima-media thickness (IMT) on incident cardiovascular disease and mortality in hemodialysis patients. Methods Multicenter, observational, prospective study including 110 patients, followed-up to 6 years. Carotid doppler ultrasonographic findings were classified in 4 degrees of severity: 1) IMT <0.9 mm, 2) IMT >0.9 mm, 3) carotid plaque with stenosis <50% and 4) plaque with stenosis >50%. The associations between IMT and CAD and cardiovascular events, total and cardiovascular mortality were assessed. Results 83% of the patients had atherosclerotic plaques (CAD degrees 3-4). During follow-up, 29.1% of patients experienced cardiovascular events, and 28.2% died, 38.7% of cardiovascular origin. The presence of plaques was associated with cardiovascular events (p = 0.03) while calcified plaques were associated with both cardiovascular events (p = 0.01), cardiovascular mortality (p = 0.03) and non-significantly with overall mortality (p = 0.08) in the survival analysis. Carotid IMT was not associated with outcomes. Cardiovascular events correlated with CAD severity (HR 2.27, 95% CI 1.13-4.54), age (HR 1.04, 1.01-1.06), previous cardiovascular disease (HR 1.75, 1.05-4.42), dyslipidemia (HR 2.25, 1.11-4.53), lipoprotein (a) (HR 1.01, 1.00-1.02), troponin I (HR 3.89, 1.07-14.18), fibrinogen levels (HR 1.38, 0.98-1.94) and antiplatelet therapy (HR 2.14, 1.04-4.4). In an age-adjusted multivariate model, cardiovascular events were independently associated with previous coronary artery disease (HR 3.29, 1.52-7.15) and lipoprotein (a) (HR 1.01, 1.00-1.02). Conclusions The presence of carotid plaques and, especially, calcified plaques, are predictors of new cardiovascular events and cardiovascular mortality in hemodialysis patients, while IMT was not. The prognostic value of calcified plaques should be confirmed in future studies.-
dc.format.extent12 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherPublic Library of Science (PLoS)-
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0127344-
dc.relation.ispartofPLoS One, 2015, vol. 10, num. 6, p. e0127344-
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0127344-
dc.rightscc-by (c) Collado, S. et al., 2015-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.sourceArticles publicats en revistes (Medicina)-
dc.subject.classificationDiàlisi-
dc.subject.classificationAterosclerosi-
dc.subject.classificationMalalties coronàries-
dc.subject.classificationEstenosi-
dc.subject.classificationMalalties del ronyó-
dc.subject.classificationHipertensió-
dc.subject.classificationEstudi de casos-
dc.subject.otherDialysis-
dc.subject.otherAtherosclerosis-
dc.subject.otherCoronary diseases-
dc.subject.otherStenosis-
dc.subject.otherKidney diseases-
dc.subject.otherHypertension-
dc.subject.otherCase studies-
dc.titleCarotid atherosclerotic disease predicts cardiovascular events in hemodialysis patients: A prospective study-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec653763-
dc.date.updated2016-10-19T08:22:26Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid26029907-
Appears in Collections:Articles publicats en revistes (Medicina)

Files in This Item:
File Description SizeFormat 
653763.pdf480.77 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons