Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/102825
Title: Improving assessment of lipoprotein profile profile in type 1 diabetes by 1H NMR spectrometry
Author: Brugnara, Laura
Mallol, Roger
Ribalta, Josep
Vinaixa Crevillent, Maria
Murillo, Serafín
Casserras, Teresa
Guardiola, Montse
Vallvé, Joan Carles
Kalko, Susana
Correig Blanchar, Xavier
Novials, Anna
Keywords: Lipoproteïnes
Diabetis
Colesterol
Teixit adipós
Malalties cardiovasculars
Olis i greixos
Ressonància magnètica nuclear
Lipoproteins
Diabetes
Cholesterol
Adipose tissues
Cardiovascular diseases
Oils and fats
Nuclear magnetic resonance
Issue Date: 28-Aug-2015
Publisher: Public Library of Science (PLoS)
Abstract: Patients with type 1 diabetes (T1D) present increased risk of cardiovascular disease (CVD). The aim of this study is to improve the assessment of lipoprotein profile in patients with T1D by using a robust developed method 1H nuclear magnetic resonance spectroscopy (1H NMR), for further correlation with clinical factors associated to CVD. Thirty patients with T1D and 30 non-diabetes control (CT) subjects, matched for gender, age, body composition (DXA, BMI, waist/hip ratio), regular physical activity levels and cardiorespiratory capacity (VO2peak), were analyzed. Dietary records and routine lipids were assessed. Serum lipoprotein particle subfractions, particle sizes, and cholesterol and triglycerides subfractions were analyzed by 1H NMR. It was evidenced that subjects with T1D presented lower concentrations of small LDL cholesterol, medium VLDL particles, large VLDL triglycerides, and total triglycerides as compared to CT subjects. Women with T1D presented a positive association with HDL size (p<0.005; R = 0.601) and large HDL triglycerides (p<0.005; R = 0.534) and negative (p<0.005; R = -0.586) to small HDL triglycerides. Body fat composition represented an important factor independently of normal BMI, with large LDL particles presenting a positive correlation to total body fat (p<0.005; R = 0.505), and total LDL cholesterol and small LDL cholesterol a positive correlation (p<0.005; R = 0.502 and R = 0.552, respectively) to abdominal fat in T1D subjects; meanwhile, in CT subjects, body fat composition was mainly associated to HDL subclasses. VO2peak was negatively associated (p<0.005; R = -0.520) to large LDL-particles only in the group of patients with T1D. In conclusion, patients with T1D with adequate glycemic control and BMI and without chronic complications presented a more favourable lipoprotein profile as compared to control counterparts. In addition, slight alterations in BMI and/or body fat composition showed to be relevant to provoking alterations in lipoproteins profiles. Finally, body fat composition appears to be a determinant for cardioprotector lipoprotein profile.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0136348
It is part of: PLoS One, 2015, vol. 10, num. 8, p. e0136348
Related resource: http://dx.doi.org/10.1371/journal.pone.0136348
URI: http://hdl.handle.net/2445/102825
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Biomedicina)

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