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http://hdl.handle.net/2445/102886
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DC Field | Value | Language |
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dc.contributor.author | Amo Moran, Eva del | - |
dc.contributor.author | Esteva, Cristina | - |
dc.contributor.author | Hernández Bou, Susanna | - |
dc.contributor.author | Galles, Carmen | - |
dc.contributor.author | Navarro, Marian | - |
dc.contributor.author | Sauca, Goretti | - |
dc.contributor.author | Díaz Conradi, Álvaro | - |
dc.contributor.author | Gassiot, Paula | - |
dc.contributor.author | Marti, Carmina | - |
dc.contributor.author | Larrosa, Nieves | - |
dc.contributor.author | Ciruela, Pilar | - |
dc.contributor.author | Jane, Mireia | - |
dc.contributor.author | Sá-Leao, Raquel | - |
dc.contributor.author | Muñoz-Almagro, Carmen | - |
dc.contributor.author | García García, Juan José | - |
dc.contributor.author | Catalan Study Group of Invasive Pneumococcal Disease [autoria conjunta] | - |
dc.date.accessioned | 2016-10-25T10:22:26Z | - |
dc.date.available | 2016-10-25T10:22:26Z | - |
dc.date.issued | 2016-03-08 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/102886 | - |
dc.description.abstract | The aim of this study was to study the serotypes and clonal diversity of pneumococci causing invasive pneumococcal disease in Catalonia, Spain, in the era of 13-valent pneumococcal conjugate vaccine (PCV13). In our region, this vaccine is only available in the private market and it is estimated a PCV13 vaccine coverage around 55% in children. A total of 1551 pneumococcal invasive isolates received between 2010 and 2013 in the Molecular Microbiology Department at Hospital Sant Joan de Déu, Barcelona, were included. Fifty-two serotypes and 249 clonal types defined by MLST were identified. The most common serotypes were serotype 1 (n = 182; 11.7%), 3 (n = 145; 9.3%), 19A (n = 137; 8.8%) and 7F (n = 122; 7.9%). Serotype 14 was the third most frequent serotype in children < 2 years (15 of 159 isolates). PCV7 serotypes maintained their proportion along the period of study, 16.6% in 2010 to 13.4% in 2013, whereas there was a significant proportional decrease in PCV13 serotypes, 65.3% in 2010 to 48.9% in 2013 (p<0.01). This decrease was mainly attributable to serotypes 19A and 7F. Serotype 12F achieved the third position in 2013 (n = 22, 6.4%). The most frequent clonal types found were ST306 (n = 154, 9.9%), ST191 (n = 111, 7.2%), ST989 (n = 85, 5.5%) and ST180 (n = 80, 5.2%). Despite their decrease, PCV13 serotypes continue to be a major cause of disease in Spain. These results emphasize the need for complete PCV13 vaccination. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0151125 | - |
dc.relation.ispartof | PLoS One, 2016, vol. 11, num. 3, p. e0151125 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0151125 | - |
dc.rights | cc-by (c) del Amo, E. et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Pneumococs | - |
dc.subject.classification | Vacunes | - |
dc.subject.classification | Pneumònia | - |
dc.subject.classification | Immunologia | - |
dc.subject.classification | Espanya | - |
dc.subject.classification | Catalunya | - |
dc.subject.other | Streptococcus pneumonia | - |
dc.subject.other | Vaccines | - |
dc.subject.other | Pneumonia | - |
dc.subject.other | Immunology | - |
dc.subject.other | Spain | - |
dc.subject.other | Catalonia | - |
dc.title | Serotypes and Clonal Diversity of Streptococcus pneumoniae Causing Invasive Disease in the Era of PCV13 in Catalonia, Spain | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 664604 | - |
dc.date.updated | 2016-10-25T10:22:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26953887 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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664604.pdf | 841.79 kB | Adobe PDF | View/Open |
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