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Title: Genetic association study of coronary collateral circulation in patients with coronary artery disease using 22 single nucleotide polymorphisms corresponding to 10 genes involved in postischemic neovascularization
Author: Duran i Ferrer, Joan, 1978-
Sánchez Olavarría, María Pilar
Mola, Marina
Götzens García, Víctor José
Carballo, Julio
Martín Pelegrina, Eva
Petit, Màrius
Abdul Jawad, Omar
Otaegui, Imanol
García del Blanco, Bruno
García Dorado, David
Reig, Josep
Cordero Casanovas, Alex
Anta i Vinyals, Josep Maria de
Keywords: Malalties coronàries
Circulació coronària
Malalties arterials
Polimorfisme genètic
Genètica molecular humana
Oclusions arterials
Coronary diseases
Coronary circulation
Arteries Diseases
Genetic polymorphisms
Human molecular genetics
Arterial occlusions
Issue Date: 12-May-2015
Publisher: BioMed Central
Abstract: Background: collateral growth in patients with coronary artery disease (CAD) is highly heterogeneous. Although multiple factors are thought to play a role in collateral development, the contribution of genetic factors to coronary collateral circulation (CCC) is largely unknown. The goal of this study was to assess whether functional single nucleotide polymorphisms (SNPs) in genes involved in vascular growth are associated with CCC. Methods: 677 consecutive CAD patients were enrolled in the study and their CCC was assessed by the Rentrop method. 22 SNPs corresponding to 10 genes involved in postischemic neovascularization were genotyped and multivariate logistic regression models were adjusted using clinically relevant variables to estimate odds ratios and used to examine associations of allelic variants, genotypes and haplotypes with CCC. Results: statistical analysis showed that the HIF1A rs11549465 and rs2057482; VEGFA rs2010963, rs1570360, rs699947, rs3025039 and rs833061; KDR rs1870377, rs2305948 and rs2071559; CCL2 rs1024611, rs1024610, rs2857657 and rs2857654; NOS3 rs1799983; ICAM1 rs5498 and rs3093030; TGFB1 rs1800469; CD53 rs6679497; POSTN rs3829365 and rs1028728; and LGALS2 rs7291467 polymorphisms, as well as their haplotype combinations, were not associated with CCC (p < 0.05). Conclusions: we could not validate in our cohort the association of the NOS3 rs1799983, HIF1A rs11549465, VEGFA rs2010963 and rs699947, and LGALS2 rs7291467 variants with CCC reported by other authors. A validated SNP-based genome-wide association study is required to identify polymorphisms influencing CCC.
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It is part of: BMC Cardiovascular Disorders, 2015, vol. 15, p. 37
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ISSN: 1471-2261
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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