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DC Field | Value | Language |
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dc.contributor.author | Sued, Omar | - |
dc.contributor.author | Ambrosioni, Juan | - |
dc.contributor.author | Nicolás, David | - |
dc.contributor.author | Manzardo, Christian | - |
dc.contributor.author | Agüero Santangelo, Fernando | - |
dc.contributor.author | Claramonte, Xavier | - |
dc.contributor.author | Plana Prades, Montserrat | - |
dc.contributor.author | Tuset Creus, Montserrat | - |
dc.contributor.author | Pumarola Suñé, Tomàs | - |
dc.contributor.author | Gallart, Teresa | - |
dc.contributor.author | Gatell, José M. | - |
dc.contributor.author | Miró Meda, José M. | - |
dc.date.accessioned | 2016-10-31T14:58:35Z | - |
dc.date.available | 2016-10-31T14:58:35Z | - |
dc.date.issued | 2015-07-17 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/103067 | - |
dc.description.abstract | BACKGROUND: Interventions during primary HIV infection (PHI) can modify the clinical course during the chronic phase. The long-term effect of structured treatment interruptions (STI) followed by low doses of interleukin-2 (IL-2) in treated PHI patients is unknown. METHODS: Twelve PHI patients with viral load (VL) <20 copies/mL, CD4 cells >500 cells/mm3, and CD4/CD8 ratio >1, on antiretroviral therapy (ART) initiated within the first 90 days of infection and continued for at least 12 months were included. They underwent four STI and were then allocated (week 0 of the study) to ART alone or ART plus low doses of IL-2. ART was stopped once VL <20 copies/mL ('final stop'). Primary endpoints were VL<3000 copies/mL and CD4 cells >500 cells/mm3 at 48 weeks; secondary endpoints were immune activation, inflammatory markers until 48 weeks and the time before resuming ART (CD4 <350 cells/mm3 or AIDS) after 'final stop', compared between groups. RESULTS: Ten out of 12 patients were males, median age was 35 years and the main risk was men-who-have-sex-with-men. Only one out of 12 patients (in the STI group) maintained VL<3000 copies/mL and CD4 cells >500 cells/mm3 without ART at 48 weeks. All other virological and immunological parameters were comparable between groups at week 0, 'final stop' and week 48. However, the proportion of CD8-CD38+ cells, tumor necrosis factor and srIL-2 were higher in the IL-2 group at 'final stop' and week 24. All these differences vanished during follow-up. At 5 years after the final stop 3 out of 6 patients in the IL-2 group and 6 out of 6 patients in the STI group have resumed ART (P = 0.19). CONCLUSIONS: STI and IL-2 failed to achieve virological control after ART interruption. STI were not deleterious in long-term follow-up, an important issue for eradication and functional cure trials. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0131651 | - |
dc.relation.ispartof | PLoS One, 2015, vol. 10, num. 7, p. e0131651 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0131651 | - |
dc.rights | cc-by (c) Sued, O. et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Antiretrovirals | - |
dc.subject.classification | Infeccions per VIH | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.classification | Resposta immunitària | - |
dc.subject.classification | Inflamació | - |
dc.subject.other | Antiretroviral agents | - |
dc.subject.other | HIV infections | - |
dc.subject.other | HIV (Viruses) | - |
dc.subject.other | Immune response | - |
dc.subject.other | Inflammation | - |
dc.title | Structured Treatment Interruptions and Low Doses of IL-2 in Patients with Primary HIV Infection. Inflammatory, Virological and Immunological Outcomes | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 660769 | - |
dc.date.updated | 2016-10-31T14:58:40Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26186440 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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