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Title: Synergistic antipseudomonal effects of synthetic peptide AMP38 and carbapenems
Author: Rudilla, Héctor
Fusté i Domínguez, Ester
Cajal Visa, Yolanda
Rabanal Anglada, Francesc
Vinuesa Aumedes, Teresa
Viñas, Miquel
Keywords: Pseudomonas
Síntesi de pèptids
Peptide synthesis
Issue Date: 12-Sep-2016
Publisher: MDPI
Abstract: The aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or alteration of protein OprD. Time-kill and minimal biofilm eradication concentration (MBEC) determinations were carried out by using clinical imipenem-resistant strains. AMP38 was markedly synergistic with imipenem when determined in imipenem-resistant P. aeruginosa. MBEC obtained for the combination of AMP38 and imipenem was of 62.5 μg/mL, whereas the MBEC of each antimicrobial separately was 500 μg/mL. AMP38 should be regarded as a promising antimicrobial to fight MDR P. aeruginosa infections. Moreover, killing effect and antibiofilm activity of AMP38 plus imipenem was much higher than that of colistin plus imipenem.
Note: Reproducció del document publicat a:
It is part of: Molecules, 2016, vol. 21, num. 9, p. 1223
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ISSN: 1420-3049
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Química Inorgànica i Orgànica)
Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))

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