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http://hdl.handle.net/2445/103103
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DC Field | Value | Language |
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dc.contributor.author | Rudilla Mateo, Héctor | - |
dc.contributor.author | Fusté i Domínguez, Ester | - |
dc.contributor.author | Cajal Visa, Yolanda | - |
dc.contributor.author | Rabanal Anglada, Francesc | - |
dc.contributor.author | Vinuesa Aumedes, Teresa | - |
dc.contributor.author | Viñas, Miquel | - |
dc.date.accessioned | 2016-11-02T09:16:37Z | - |
dc.date.available | 2016-11-02T09:16:37Z | - |
dc.date.issued | 2016-09-12 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/2445/103103 | - |
dc.description.abstract | The aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or alteration of protein OprD. Time-kill and minimal biofilm eradication concentration (MBEC) determinations were carried out by using clinical imipenem-resistant strains. AMP38 was markedly synergistic with imipenem when determined in imipenem-resistant P. aeruginosa. MBEC obtained for the combination of AMP38 and imipenem was of 62.5 μg/mL, whereas the MBEC of each antimicrobial separately was 500 μg/mL. AMP38 should be regarded as a promising antimicrobial to fight MDR P. aeruginosa infections. Moreover, killing effect and antibiofilm activity of AMP38 plus imipenem was much higher than that of colistin plus imipenem. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/molecules21091223 | - |
dc.relation.ispartof | Molecules, 2016, vol. 21, num. 9, p. 1223 | - |
dc.relation.uri | https://doi.org/10.3390/molecules21091223 | - |
dc.rights | cc-by (c) Rudilla, Héctor et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Pseudomonas | - |
dc.subject.classification | Síntesi de pèptids | - |
dc.subject.classification | Pèptids | - |
dc.subject.classification | Biofilms | - |
dc.subject.classification | Antibiòtics | - |
dc.subject.other | Pseudomonas | - |
dc.subject.other | Peptide synthesis | - |
dc.subject.other | Peptides | - |
dc.subject.other | Biofilms | - |
dc.subject.other | Antibiotics | - |
dc.title | Synergistic antipseudomonal effects of synthetic peptide AMP38 and carbapenems | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 663969 | - |
dc.date.updated | 2016-11-02T09:16:42Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27626405 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB)) |
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663969.pdf | 1 MB | Adobe PDF | View/Open |
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