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Title: Longer telomeres are associated with cancer risk in MMR-proficient hereditary non-polyposis colorectal cancer
Author: Seguí Gracia, Nuria
Guinó, Elisabet
Pineda Riu, Marta
Navarro, Matilde
Bellido Molías, Fernando
Lázaro García, Conxi
Blanco Guillermo, Ignacio
Moreno Aguado, Víctor
Capellá, G. (Gabriel)
Valle Velasco, Laura
Keywords: Telòmer
Genètica humana
Càncer colorectal
Malalties hereditàries
Factors de risc en les malalties
Human genetics
Colorectal cancer
Genetic diseases
Risk factors in diseases
Issue Date: 3-Feb-2014
Publisher: Public Library of Science (PLoS)
Abstract: Aberrant telomere length measured in blood has been associated with increased risk of several cancer types. In the field of hereditary non-polyposis colorectal cancer (CRC), and more particularly in Lynch syndrome, caused by germline mutations in the mismatch repair (MMR) genes, we recently found that cancer-affected MMR gene mutation carriers had shorter telomeres and more pronounced shortening of telomere length with age than controls and unaffected MMR gene mutation carriers. Here we evaluate blood telomere length in MMR-proficient hereditary non-polyposis CRC, i.e. familial CRC type X (fCRC-X). A total of 57 cancer-affected and 57 cancer-free individuals from 34 Amsterdam-positive fCRC-X families were analyzed and compared to the data previously published on 144 cancer-affected and 100 cancer-free MMR gene mutation carriers, and 234 controls. Relative telomere length was measured using a monochrome multiplex quantitative PCR method, following strict measures to avoid sources of bias and adjusting by age. Despite the retrospective nature of our study, the results show that longer telomeres associate with cancer risk in fCRC-X, thus identifying different patterns of telomere length according to the status of the MMR system.
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It is part of: PLoS One, 2014, vol. 9, num. 2, p. e86063
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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