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Title: The role of the c-Jun N-terminal kinase (JNK) pathway in insulin resistance
Author: Caelles Franch, Carme
Lanuza Masdeu, Jordi
Arévalo, M. Isabel
Díaz-Delfín, Julieta
Morcillo, Melisa
Bayod giron, Carles
Keywords: Resistència a la insulina
Diabetis no-insulinodependent
Insulin resistance
Non-insulin-dependent diabetes
Issue Date: 2016
Publisher: Research Signpost
Abstract: Obesity is usually associated with a decreased response to insulin, a major metabolic defect known as insulin resistance and an early trait in the development of type 2 diabetes. The c-Jun N-terminal kinase (JNK) pathway has emerged as a central regulator of insulin sensitivity, locally and systemically, thereby, of body’s metabolic homeostasis. As the incidence of obesity and type 2 diabetes has alarmingly increased in the last few decades, there is a tremendous necessity to identify novel pharmacological targets to efficiently improve the therapeutic outcome. In this regard, the JNK pathway seems to meet most of the requirements for being an adequate candidate to direct pharmacological intervention.
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It is part of: Recent Advances in Pharmaceutical Sciences VI, 2016, Research Signpost. Editors: Diego Muñoz Torrero, Àngela Domínguez García & Ma. Ángeles Manresa Presas. ISBN: 978-81-308-0566-5. Chapter 5, p. 76-90.
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Appears in Collections:Llibres / Capítols de llibre (Bioquímica i Fisiologia)

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