Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/103923
Title: Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women
Author: Requena, Pilar
Rui, Edmilson
Padilla, Norma
Martínez Espinosa, Flor E.
Castellanos, Maria Eugenia
Botto Menezes, Camila
Malheiro, Adriana
Arévalo Herrera, Myriam
Kochar, Swati
Kochar, Sanjay K.
Kochar, Dhanpat K.
Umbers, Alexandra J.
Ome Kaius, Maria
Wangnapi, Regina
Hans, Dhiraj
Menegon, Michela
Mateo, Francesca
Sanz, Sergi
Desai, Meghna
Mayor Aparicio, Alfredo Gabriel
Chitnis, Chetan
Bardají, Azucena
Mueller, Ivo
Rogerson, Stephen
Severini, Carlo
Fernández Becerra, Carmen
Menéndez, Clara
Portillo Obando, Hernando A. del
Dobaño, Carlota, 1969-
Keywords: Plasmodium vivax
Malària
Immunoglobulines
Embarassades
Plasmodium vivax
Malaria
Immunoglobulins
Pregnant women
Issue Date: 6-Oct-2016
Publisher: Public Library of Science (PLoS)
Abstract: P. vivax infection during pregnancy has been associated with poor outcomes such as anemia, low birth weight and congenital malaria, thus representing an important global health problem. However, no vaccine is currently available for its prevention. Vir genes were the first putative virulent factors associated with P. vivax infections, yet very few studies have examined their potential role as targets of immunity. We investigated the immunogenic properties of five VIR proteins and two long synthetic peptides containing conserved VIR sequences (PvLP1 and PvLP2) in the context of the PregVax cohort study including women from five malaria endemic countries: Brazil, Colombia, Guatemala, India and Papua New Guinea (PNG) at different timepoints during and after pregnancy. Antibody responses against all antigens were detected in all populations, with PNG women presenting the highest levels overall. P. vivax infection at sample collection time was positively associated with antibody levels against PvLP1 (fold-increase: 1.60 at recruitment -first antenatal visit-) and PvLP2 (fold-increase: 1.63 at delivery), and P. falciparum co-infection was found to increase those responses (for PvLP1 at recruitment, fold-increase: 2.25). Levels of IgG against two VIR proteins at delivery were associated with higher birth weight (27 g increase per duplicating antibody levels, p<0.05). Peripheral blood mononuclear cells from PNG uninfected pregnant women had significantly higher antigen-specific IFN-gamma TH1 responses (p=0.006) and secreted less pro-inflammatory cytokines TNF and IL-6 after PvLP2 stimulation than P. vivax-infected women (p<0.05). These data demonstrate that VIR antigens induce the natural acquisition of antibody and T cell memory responses that might be important in immunity to P. vivax during pregnancy in very diverse geographical settings.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pntd.0005009
It is part of: PLoS Neglected Tropical Diseases, 2016, vol. 10, num. 10, p. e0005009
Related resource: http://dx.doi.org/10.1371/journal.pntd.0005009
URI: http://hdl.handle.net/2445/103923
ISSN: 1935-2727
Appears in Collections:Articles publicats en revistes (ISGlobal)

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