Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/104024
Title: Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients
Author: García Bermúdez, Mercedes
González Juanatey, Carlos
López Mejías, Raquel
Teruel, María
Corrales, Alfonso
Miranda Filloy, José A.
Castañeda, Santos
Balsa, Alejandro
Fernández Gutiérrez, Benjamín B
González Álvaro, Isidoro
Gómez Vaquero, Carmen
Blanco, Ricardo
Llorca Díaz, Javier
Martín, Javier
González Gay, Miguel A.
Keywords: Artritis reumatoide
Reumatisme
Polimorfisme genètic
Malalties cardiovasculars
Aterosclerosi
Espanya
Rheumatoid arthritis
Rheumatism
Genetic polymorphisms
Cardiovascular diseases
Atherosclerosis
Spain
Issue Date: 15-Nov-2012
Publisher: Public Library of Science (PLoS)
Abstract: Objective: rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular (CV) mortality. Since CD40-CD154 binding has direct consequences on inflammation process initiation, we aimed to replicate previous findings related to disease susceptibility in Spanish RA population. Furthermore, as the major complication in RA disease patients is the development of CV events due to accelerated atherosclerosis, and elevated levels of CD40L/CD154 are present in patients with acute myocardial infarction, we assessed the potential association of CD40 and CD154/CD40L gene variants with CV risk in Spanish RA patients. Methods: one thousand five hundred and seventy-five patients fulfilling the 1987 ACR classification criteria for RA and 1600 matched controls were genotyped for the CD40 rs1883832, rs4810485 and rs1535045 and CD154 rs3092952 and rs3092920 gene polymorphisms, using predesigned TaqMan single nucleotide polymorphism genotyping assays. Afterwards, we investigated the influence of CD40-CD154 gene variants in the development of CV events. Also, in a subgroup of 273 patients without history of CV events, we assessed the influence of these polymorphisms in the risk of subclinical atherosclerosis determined by carotid ultrasonography. Results: nominally significant differences in the allele frequencies for the rs1883832 CD40 gene polymorphism between RA patients and controls were found (p = 0.038). Although we did not observe a significant association of CD40-CD154 gene variants with the development of CV events, an ANCOVA model adjusted for sex, age at the time of the ultrasonography assessment, follow-up time, traditional CV risk factors and anti-cyclic citrullinated peptide antibodies disclosed a significant association (p = 0.0047) between CD40 rs1535045 polymorphism and carotid intima media thickness, a surrogate marker of atherosclerosis. Conclusion: data from our pilot study indicate a potential association of rs1883832 CD40 gene polymorphism with susceptibility to RA. Also, the CD40 rs1535045 gene variant may influence development of subclinical atherosclerosis in RA patients.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0049214
It is part of: PLoS One, 2012, vol. 7, num. 11, p. e49214
Related resource: https://doi.org/10.1371/journal.pone.0049214
URI: http://hdl.handle.net/2445/104024
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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