Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/104191
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Brissot, Eolia | - |
dc.contributor.author | Labopin, Myriam | - |
dc.contributor.author | Beckers, Marielle M. | - |
dc.contributor.author | Socié, Gérard | - |
dc.contributor.author | Rambaldi, Alessandro | - |
dc.contributor.author | Volin, Liisa | - |
dc.contributor.author | Finke, Jürgen | - |
dc.contributor.author | Lenhoff, Stig | - |
dc.contributor.author | Kröger, Nicolaus | - |
dc.contributor.author | Ossenkoppele, Gert J. | - |
dc.contributor.author | Craddock, Charles F. | - |
dc.contributor.author | Yakoub-Agha, Ibrahim | - |
dc.contributor.author | Gürman, Günhan | - |
dc.contributor.author | Russell, Nigel H. | - |
dc.contributor.author | Aljurf, Mahmoud | - |
dc.contributor.author | Potter, Michael N. | - |
dc.contributor.author | Nagler, Arnon | - |
dc.contributor.author | Ottmann, Oliver | - |
dc.contributor.author | Cornelissen, Jan J. | - |
dc.contributor.author | Esteve Reyner, Jordi | - |
dc.contributor.author | Mohty, Mohamad | - |
dc.date.accessioned | 2016-11-25T17:21:47Z | - |
dc.date.available | 2016-11-25T17:21:47Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 0390-6078 | - |
dc.identifier.uri | http://hdl.handle.net/2445/104191 | - |
dc.description.abstract | This study aimed to determine the impact of tyrosine kinase inhibitors given pre- and post-allogeneic stem cell transplantation on long-term outcome of patients allografted for Philadelphia chromosome-positive acute lymphoblastic leukemia. This retrospective analysis from the EBMT Acute Leukemia Working Party included 473 de novo Philadelphia chromosome-positive acute lymphoblastic leukemia patients in first complete remission who underwent an allogeneic stem cell transplantation using a human leukocyte antigen-identical sibling or human leukocyte antigen-matched unrelated donor between 2000 and 2010. Three hundred and ninety patients received tyrosine kinase inhibitors before transplant, 329 at induction and 274 at consolidation. Kaplan-Meier estimates of leukemia-free survival, overall survival, cumulative incidences of relapse incidence, and non-relapse mortality at five years were 38%, 46%, 36% and 26%, respectively. In multivariate analysis, tyrosine-kinase inhibitors given before allogeneic stem cell transplantation was associated with a better overall survival (HR=0.68; P=0.04) and was associated with lower relapse incidence (HR=0.5; P=0.01). In the post-transplant period, multivariate analysis identified prophylactic tyrosine-kinase inhibitor administration to be a significant factor for improved leukemia-free survival (HR=0.44; P=0.002) and overall survival (HR=0.42; P=0.004), and a lower relapse incidence (HR=0.40; P=0.01). Over the past decade, administration of tyrosine kinase inhibitors before allogeneic stem cell transplantation has significantly improved the long-term allogeneic stem cell transplantation outcome of adult Philadelphia chromosome-positive acute lymphoblastic leukemia. Prospective studies will be of great interest to further confirm the potential benefit of the prophylactic use of tyrosine kinase inhibitors in the post-transplant setting. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Ferrata Storti Foundation | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3324/haematol.2014.116954 | - |
dc.relation.ispartof | Haematologica, 2015, vol. 100, num. 3, p. 392-399 | - |
dc.relation.uri | https://doi.org/10.3324/haematol.2014.116954 | - |
dc.rights | (c) Ferrata Storti Foundation, 2015 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Leucèmia limfocítica crònica | - |
dc.subject.classification | Cèl·lules mare | - |
dc.subject.classification | Inhibidors enzimàtics | - |
dc.subject.other | Chronic lymphocytic leukemia | - |
dc.subject.other | Stem cells | - |
dc.subject.other | Enzyme inhibitors | - |
dc.title | Tyrosine kinase inhibitors improve long-term outcome of allogeneic hematopoietic stem cell transplantation for adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 663502 | - |
dc.date.updated | 2016-11-25T17:21:52Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25527562 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
663502.pdf | 266.17 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.