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http://hdl.handle.net/2445/104294
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DC Field | Value | Language |
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dc.contributor.author | Isetta, Valentina | - |
dc.contributor.author | Montserrat Canal, José Ma. | - |
dc.contributor.author | Santano, Raquel | - |
dc.contributor.author | Wimms, Alison J. | - |
dc.contributor.author | Ramanan, Dinesh | - |
dc.contributor.author | Woehrle, Holger | - |
dc.contributor.author | Navajas Navarro, Daniel | - |
dc.contributor.author | Farré Ventura, Ramon | - |
dc.date.accessioned | 2016-11-30T12:15:04Z | - |
dc.date.available | 2016-11-30T12:15:04Z | - |
dc.date.issued | 2016-03-15 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/104294 | - |
dc.description.abstract | Bench testing is a useful method to characterize the response of different automatic positive airway pressure (APAP) devices under well-controlled conditions. However, previous mod- els did not consider the diversity of obstructive sleep apnea (OSA) patients ' characteristics and phenotypes. The objective of this proof-of-concept study was to design a new bench test for realistically simulating an OSA patient ' s night, and to implement a one-night exam- ple of a typical female phenotype for comparing responses to several currently-available APAP devices. We developed a novel approach aimed at replicating a typical night of sleep which includes different disturbed breathing events, disease severities, sleep/wake phases, body postures and respiratory artefacts. The simulated female OSA patient example that we implemented included periods of wake, light sleep and deep sleep with positional changes and was connected to ten different APAP devices. Flow and pressure readings were recorded; each device was tested twice. The new approach for simulating female OSA patients effectively combined a wide variety of disturbed breathing patterns to mimic the response of a predefined patient type. There were marked differences in response between devices; only three were able to overcome flow limitation to normalize breathing, and only five devices were associated with a residual apnea-hypopnea index of < 5/h. In conclusion, bench tests can be designed to simulate specific patient characteristics, and typical stages of sleep, body position, and wake. Each APAP device behaved differently when exposed to this controlled model of a female OSA patient, and should lead to further understanding of OSA treatment. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0151530 | - |
dc.relation.ispartof | PLoS One, 2016, vol. 11, num. 3, p. e0152124 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0151530 | - |
dc.rights | cc-by (c) Isetta, Valentina et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Síndromes d'apnea del son | - |
dc.subject.classification | Fisiologia del son | - |
dc.subject.classification | Dones | - |
dc.subject.classification | Trastorns del son | - |
dc.subject.classification | Deglutició | - |
dc.subject.classification | Algorismes | - |
dc.subject.other | Sleep apnea syndromes | - |
dc.subject.other | Sleep physiology | - |
dc.subject.other | Women | - |
dc.subject.other | Sleep disorders | - |
dc.subject.other | Deglutition | - |
dc.subject.other | Algorithms | - |
dc.title | Novel approach to simulate sleep apnoea patients for evaluating positive pressure therapy devices | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 668390 | - |
dc.date.updated | 2016-11-30T12:15:10Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26978077 | - |
Appears in Collections: | Articles publicats en revistes (Biomedicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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668390.pdf | 555.84 kB | Adobe PDF | View/Open |
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