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Title: Chronic hypoxia induced ultrastructural changes in the rat adrenal zona glomerulosa
Author: Lorente, M.
Miralpeix, R.M.
Miguel Pérez, Ma. Isabel
Longmei, W.
Volk, D.
Cervós i Navarro, Jordi, 1930-
Keywords: Glàndules suprarenals
Rates (Animals de laboratori)
Oxigen en l'organisme
Ultraestructura (Biologia)
Malalties cròniques
Adrenal glands
Rats as laboratory animals
Oxygen in the body
Ultrastructure (Biology)
Chronic diseases
Issue Date: Jan-2002
Publisher: Universidad de Murcia
Abstract: The adrenal cortex plays an important role in adaptation to various forms of stress, including hypoxia. While physiological changes in the aldosterone metabolism during hypoxia have been extensively described, few studies have focused on the morphological changes in the adrenal glands under chronic hypoxia. We studied the ultrastructure of the zona glomerulosa of 6-month-old Wistar rats exposed to chronic normobaric hypoxia. Animals were divided into two groups: control (n=12) and hypoxic (n=12). In this latter group, the animals were kept at 7% O2 concentration after a gradual adaptation (21, 15, 12, 10, 8, 7 vol% O2 ). The duration of the study was 112 days. In comparison with normoxic rats, body weight and adrenal gland weight of hypoxic animals was significantly reduced by 18.5% (p=0.006) and 14.7% (p=0.001) respectively. The thickness of the zona glomerulosa decreased due to atrophy of cells. The main ultrastructural changes observed were: 1) a decrease in, or complete limination of, lipid droplet content; 2) a marked increase in lysosome number; and 3) the presence of giant mitochondria. Our findings show that rats fail to adapt to severe chronic hypoxia. The ultrastructural changes in the zona glomerulosa found in the present study could reflect changes in the aldosterone pathway.
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It is part of: Histology and Histopathology, 2002, vol. 17, num. 1, p. 185-190
ISSN: 0213-3911
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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