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Title: FOXP1 molecular cytogenetics and protein expression analyses in primary cutaneous large B cell lymphoma, leg-type
Author: Espinet Solà, Blanca
García Herrera, Adriana
Gallardo, Fernando
Baró, Cristina
Salgado, Rocío
Servitje Bedate, Octavio
Estrach Panella, Ma. Teresa (María Teresa)
Colomo Saperas, Lluís
Romagosa, Vicenç
Barranco, Carlos
Serrano, Sergi
Campo Güerri, Elias
Pujol, Ramon M.
Solé Ristol, Francesc
Keywords: Limfomes
Cèl·lules B
Càncer de pell
B cells
Skin cancer
Issue Date: Feb-2011
Publisher: Universidad de Murcia
Abstract: FOXP1 protein is expressed in normal activated B cells and overexpressed in a subset of diffuse large B-cell lymphomas, including primary cutaneous large B-cell lymphomas (PCLBCL), leg type. High expression of FOXP1 has been associated to an unfavourable prognosis with independent survival significance. However, little is known regarding the mechanisms underlying the overexpression of FOXP1 in PCLBCL, leg type. Our aims were to analyze FOXP1 cytogenetic status and protein expression in a series of PCLBCL, leg type. Finally, we compared the observed results with those obtained in a group of patients with primary cutaneous follicle centre lymphoma (PCFCL). Fifteen patients with PCLBCL, leg type and nine patients with primary cutaneous follicle centre lymphoma (PCFCL) were included in the study. For each biopsy specimen, FOXP1 translocation and copy number changes were evaluated by fluorescence in situ hybridization (FISH) and protein expression by immunohistochemistry (IHC). Immunohistochemistry showed FOXP1 staining in 13 PCLBCL, leg type, whereas all PCFCL were negative. FISH analysis disclosed no translocations involving FOXP1 gene in any of the cases. However, FOXP1 gene gains (3 to 4 copies) were observed in 82% of samples of PCLBCL, leg type and in 37% of PCFCL. FOXP1 expression was independent from FOXP1 translocation. Our results confirm that overexpression of FOXP1 is present in a considerable proportion of PCLBCL, leg type and might indicate an unfavourable prognosis. Mechanisms not related to translocation seem to be responsible for this overexpression.
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It is part of: Histology and Histopathology, 2011, vol. 26, num. 2, p. 213-221
ISSN: 0213-3911
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (Medicina)

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