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Title: Integrating genetic, neuropsychological and neuroimaging data to model early-onset obsessive compulsive disorder severity
Author: Mas Herrero, Sergi
Gassó Astorga, Patricia
Morer Liñán, Astrid
Calvo, Anna
Bargalló Alabart, Núria​
Lafuente, Amàlia, 1952-
Lázaro García, Luisa
Keywords: Neurosi obsessiva
Genètica humana
Ressonància magnètica
Diagnòstic per la imatge
Obsessive-compulsive disorder
Human genetics
Magnetic resonance
Diagnostic imaging
Issue Date: 12-Apr-2016
Publisher: Public Library of Science (PLoS)
Abstract: We propose an integrative approach that combines structural magnetic resonance imaging data (MRI), diffusion tensor imaging data (DTI), neuropsychological data, and genetic data to predict early-onset obsessive compulsive disorder (OCD) severity. From a cohort of 87 patients, 56 with complete information were used in the present analysis. First, we performed a multivariate genetic association analysis of OCD severity with 266 genetic polymorphisms. This association analysis was used to select and prioritize the SNPs that would be included in the model. Second, we split the sample into a training set (N = 38) and a validation set (N = 18). Third, entropy-based measures of information gain were used for feature selection with the training subset. Fourth, the selected features were fed into two supervised methods of class prediction based on machine learning, using the leave-one-out procedure with the train- ing set. Finally, the resulting model was validated with the validation set. Nine variables were used for the creation of the OCD severity predictor, including six genetic polymorphisms and three variables from the neuropsychological data. The developed model classified child and adolescent patients with OCD by disease severity with an accuracy of 0.90 in the testing set and 0.70 in the validation sample. Above its clinical applicability, the combination of particular neuropsychological, neuroimaging, and genetic characteristics could enhance our under- standing of the neurobiological basis of the disorder.
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It is part of: PLoS One, 2016, vol. 11, num. 4, p. e0153846
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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