Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/104863
Title: Synthesis of fluvirucins and their aglycons, the fluvirucinins
Author: Amat Tusón, Mercedes
Llor Brunés, Núria
Guignard, Guillaume
Bosch Cartes, Joan
Keywords: Lactames
Glucòsids
Lactams
Glucosides
Issue Date: 23-Jun-2016
Publisher: Universidad Nacional de La Plata
Abstract: Fluvirucins are bioactive macrolactam glycosides isolated from actinomycetes. This review gives an overview of this family of natural products, covering isolation, biological activities, biosynthesis, and total synthesis. The synthesis of fluvirucins and their aglycons, the fluvirucinins, is presented, paying special attention to the synthetic strategy and stereochemical aspects. 1 Introduction 2 Isolation, Biological Activity, and Biosynthesis 3 Synthetic Approaches 3.1 Closure of the 14-Membered Ring by Ring-Closing Metathesis 3.2 Closure of the 14-Membered Ring by Macrolactamization 3.3 Construction of the 14-Membered Ring by Aza-Claisen Ring Expansion 4 Conclusion
Note: Reproducció del document publicat a: https://doi.org/10.1055/s-0035-1561469
It is part of: Synthesis, 2016, vol. 48, num. 17, p. 2705-2720
Related resource: https://doi.org/10.1055/s-0035-1561469
URI: http://hdl.handle.net/2445/104863
ISSN: 0328-1205
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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