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Title: Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia
Author: Montull, Beatriz
Menéndez, Rosario
Torres Martí, Antoni
Reyes, Soledad
Méndez, Raúl
Zalacaín, Rafael
Capelastegui, Alberto
Rajas, Olga
Borderías, Luis
Martín Villasclaras, Juan
Bello, Salvador
Alfageme, Inmaculada
Rodríguez de Castro, Felipe
Rello Condomines, Jordi
Molinos, Luis
Ruiz Manzano, Juan
Keywords: Septicèmia
Malalties pulmonars obstructives cròniques
Chronic obstructive pulmonary diseases
Issue Date: 4-Jan-2016
Publisher: Public Library of Science (PLoS)
Abstract: Background Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). Objective To determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP. Results We performed a prospective multicenter cohort study in 13 Spanish hospital, on 4070 hospi- talized CAP patients, 1529 of whom (37.6%) presented with severe sepsis. Severe sepsis CAP was independently associated with older age ( > 65 years), alcohol abuse (OR, 1.31; 95% CI, 1.07 - 1.61), chronic obstructive pulmonary disease (COPD) (OR, 1.75; 95% CI, 1.50 - 2.04) and renal disease (OR, 1.57; 95% CI, 1.21 - 2.03), whereas prior antibiotic treat- ment was a protective factor (OR, 0.62; 95% CI, 0.52 - 0.73). Bacteremia (OR, 1.37; 95% CI, 1.05 - 1.79), S pneumoniae (OR, 1.59; 95% CI, 1.31 - 1.95) and mixed microbial etiology (OR, 1.65; 95% CI, 1.10 - 2.49) were associated with severe sepsis CAP. Conclusions CAP patients with COPD, renal disease and alcohol abuse, as well as those with CAP due to S pneumonia or mixed micro-organisms are more likely to present to the hospital with severe sepsis.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2016, vol. 11, num. 1, p. e0145929
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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