Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/105204
Title: Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls
Author: Solé Padullés, Cristina
Castro Fornieles, Josefina
Serna Gómez, Elena de la
Romero Chavarria, Soledad
Calvo, Anna
Sanchez-Gistau, Vanessa
Padrós-Fornieles, Marta
Baeza, Inmaculada
Bargalló Alabart, Núria​
Frangou, Sophia
Sugranyes, Gisela
Keywords: Trastorn bipolar
Adolescents
Esquizofrènia
Sistema nerviós
Manic-depressive illness
Teenagers
Schizophrenia
Nervous system
Issue Date: 17-Feb-2016
Publisher: Public Library of Science (PLoS)
Abstract: Schizophrenia (SZ) and bipolar disorder (BD) share clinical features, genetic risk factors and neuroimaging abnormalities. There is evidence of disrupted connectivity in resting state networks in patients with SZ and BD and their unaffected relatives. Resting state networks are known to undergo reorganization during youth coinciding with the period of increased incidence for both disorders. We therefore focused on characterizing resting state network connectivity in youth at familial risk for SZ or BD to identify alterations arising during this period. We measured resting-state functional connectivity in a sample of 106 youth, aged 7-19 years, comprising offspring of patients with SZ (N = 27), offspring of patients with BD (N = 39) and offspring of community control parents (N = 40). We used Independent Component Analysis to assess functional connectivity within the default mode, executive control, salience and basal ganglia networks and define their relationship to grey matter volume, clinical and cognitive measures. There was no difference in connectivity within any of the networks examined between offspring of patients with BD and offspring of community controls. In contrast, offspring of patients with SZ showed reduced connectivity within the left basal ganglia network compared to control offspring, and they showed a positive correlation between connectivity in this network and grey matter volume in the left caudate. Our findings suggest that dysconnectivity in the basal ganglia network is a robust correlate of familial risk for SZ and can be detected during childhood and adolescence.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0148045
It is part of: PLoS One, 2016, vol. 11, num. 2, p. e0148045
Related resource: https://doi.org/10.1371/journal.pone.0148045
URI: http://hdl.handle.net/2445/105204
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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