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Title: The possible future roles for IPSC-Derived therapy for Autoimmune Diseases.
Author: Hew, Meilyn
O´Connor, Kevin
Edel, Michael John
Lucas, Michaela
Keywords: Cèl·lules mare
Teràpia cel·lular
Stem cells
Cellular therapy
Issue Date: 28-May-2015
Publisher: MDPI
Abstract: The ability to generate inducible pluripotent stem cells (iPSCs) and the potential for their use in treatment of human disease is of immense interest. Autoimmune diseases, with their limited treatment choices are a potential target for the clinical application of stem cell and iPSC technology. IPSCs provide three potential ways of treating autoimmune disease; (i) providing pure replacement of lost cells (immuno-reconstitution); (ii) through immune-modulation of the disease process in vivo; and (iii) for the purposes of disease modeling in vitro. In this review, we will use examples of systemic, system-specific and organ-specific autoimmunity to explore the potential applications of iPSCs for treatment of autoimmune diseases and review the evidence of iPSC technology in auto-immunity to date.
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It is part of: Journal of Clinical Medicine, 2015, vol. 4, num. 6, p. 1193-1206
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ISSN: 2077-0383
Appears in Collections:Articles publicats en revistes (Biomedicina)

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