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Title: | The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature |
Author: | Díaz Beyà, Marina Brunet, Salut Nomdedéu Guinot, Josep Francesc Pratcorona, Marta Cordeiro Santanach, Anna Gallardo Giralt, David Escoda, Lourdes Tormo, Mar Heras, Inmaculada Ribera, Josep Maria Duarte, Rafael Queipo de Llano, María Paz Bargay, Joan Sampol, Antonia Nomdedeu i Fàbrega, Meritxell Risueño, Ruth M. Hoyos Colell, Montserrat Sierra Gil, Jorge Monzó Planella, Mariano Navarro Ponz, Alfons Esteve Reyner, Jordi |
Keywords: | Leucèmia mieloide Micro RNAs Genètica molecular humana Myeloid leukemia MicroRNAs Human molecular genetics |
Issue Date: | 11-Sep-2015 |
Publisher: | Impact Journals |
Abstract: | Long non-coding RNAs (lncRNAs) are deregulated in several tumors, although their role in acute myeloid leukemia (AML) is mostly unknown.We have examined the expression of the lncRNA HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) in 241 AML patients. We have correlated HOTAIRM1 expression with a miRNA expression profile. We have also analyzed the prognostic value of HOTAIRM1 expression in 215 intermediate-risk AML (IR-AML) patients.The lowest expression level was observed in acute promyelocytic leukemia (P < 0.001) and the highest in t(6;9) AML (P = 0.005). In 215 IR-AML patients, high HOTAIRM1 expression was independently associated with shorter overall survival (OR:2.04;P = 0.001), shorter leukemia-free survival (OR:2.56; P < 0.001) and a higher cumulative incidence of relapse (OR:1.67; P = 0.046). Moreover, HOTAIRM1 maintained its independent prognostic value within the favorable molecular subgroup (OR: 3.43; P = 0.009). Interestingly, HOTAIRM1 was overexpressed in NPM1-mutated AML (P < 0.001) and within this group retained its prognostic value (OR: 2.21; P = 0.01). Moreover, HOTAIRM1 expression was associated with a specific 33-microRNA signature that included miR-196b (P < 0.001). miR-196b is located in the HOX genomic region and has previously been reported to have an independent prognostic value in AML. miR-196b and HOTAIRM1 in combination as a prognostic factor can classify patients as high-, intermediate-, or low-risk (5-year OS: 24% vs 42% vs 70%; P = 0.004).Determination of HOTAIRM1 level at diagnosis provided relevant prognostic information in IR-AML and allowed refinement of risk stratification based on common molecular markers. The prognostic information provided by HOTAIRM1 was strengthened when combined with miR-196b expression. Furthermore, HOTAIRM1 correlated with a 33-miRNA signature. |
Note: | Reproducció del document publicat a: https://doi.org/10.18632/oncotarget.5148 |
It is part of: | Oncotarget, 2015, vol. 6, num. 31, p. 31613-31627 |
URI: | http://hdl.handle.net/2445/105461 |
Related resource: | https://doi.org/10.18632/oncotarget.5148 |
ISSN: | 1949-2553 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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