Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/105461
Title: The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature
Author: Díaz Beyá, Marina
Brunet, Salut
Nomdedéu Guinot, Josep Francesc
Pratcorona, Marta
Cordeiro Santanach, Anna
Gallardo Giralt, David
Escoda, Lourdes
Tormo, Mar
Heras, Inmaculada
Ribera, Josep Maria
Duarte, Rafael
Queipo de Llano, María Paz
Bargay, Joan
Sampol, Antonia
Nomdedeu i Fàbrega, Meritxell
Risueño, Ruth M.
Hoyos Colell, Montserrat
Sierra Gil, Jorge
Monzó Planella, Mariano
Navarro Ponz, Alfons
Esteve Reyner, Jordi
Keywords: Leucèmia mieloide
Micro RNAs
Genètica molecular humana
Myeloid leukemia
MicroRNAs
Human molecular genetics
Issue Date: 11-Sep-2015
Publisher: Impact Journals
Abstract: Long non-coding RNAs (lncRNAs) are deregulated in several tumors, although their role in acute myeloid leukemia (AML) is mostly unknown.We have examined the expression of the lncRNA HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) in 241 AML patients. We have correlated HOTAIRM1 expression with a miRNA expression profile. We have also analyzed the prognostic value of HOTAIRM1 expression in 215 intermediate-risk AML (IR-AML) patients.The lowest expression level was observed in acute promyelocytic leukemia (P < 0.001) and the highest in t(6;9) AML (P = 0.005). In 215 IR-AML patients, high HOTAIRM1 expression was independently associated with shorter overall survival (OR:2.04;P = 0.001), shorter leukemia-free survival (OR:2.56; P < 0.001) and a higher cumulative incidence of relapse (OR:1.67; P = 0.046). Moreover, HOTAIRM1 maintained its independent prognostic value within the favorable molecular subgroup (OR: 3.43; P = 0.009). Interestingly, HOTAIRM1 was overexpressed in NPM1-mutated AML (P < 0.001) and within this group retained its prognostic value (OR: 2.21; P = 0.01). Moreover, HOTAIRM1 expression was associated with a specific 33-microRNA signature that included miR-196b (P < 0.001). miR-196b is located in the HOX genomic region and has previously been reported to have an independent prognostic value in AML. miR-196b and HOTAIRM1 in combination as a prognostic factor can classify patients as high-, intermediate-, or low-risk (5-year OS: 24% vs 42% vs 70%; P = 0.004).Determination of HOTAIRM1 level at diagnosis provided relevant prognostic information in IR-AML and allowed refinement of risk stratification based on common molecular markers. The prognostic information provided by HOTAIRM1 was strengthened when combined with miR-196b expression. Furthermore, HOTAIRM1 correlated with a 33-miRNA signature.
Note: Reproducció del document publicat a: https://doi.org/10.18632/oncotarget.5148
It is part of: Oncotarget, 2015, vol. 6, num. 31, p. 31613-31627
Related resource: https://doi.org/10.18632/oncotarget.5148
URI: http://hdl.handle.net/2445/105461
ISSN: 1949-2553
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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