Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/105544
Title: | Somatic calreticulin mutations in patients with Budd-Chiari syndrome and portal vein thrombosis |
Author: | Plompen, Elisabeth P.C. Valk, Peter J.M. Chu, Isabel Murad, Sarwa D. Plessier, Aurélie Turon, Fanny Trebicka, Jonel Primignani, Massimo García Pagán, Juan Carlos Valla, Dominique Janssen, Harry L.A. Leebeek, Frank W. G. |
Keywords: | Hipertensió portal Malalties del fetge Mutació (Biologia) Síndrome de Budd-Chiari Portal hypertension Liver diseases Mutation (Biology) Budd–Chiari syndrome |
Issue Date: | Jun-2015 |
Publisher: | Ferrata Storti Foundation |
Abstract: | We studied the role of the recently identified CALR mutations in 141 patients with Budd-Chiari Syndrome (BCS) or portal vein thrombosis (PVT) in a large multinational cohort. A CALR mutation was present in one of the 141 patients (0.7%). This patient was previously diagnosed with primary myelofibrosis. This results in CALR positivity in one out of 44 (2.3%) patients with myeloproliferative neoplasm (MPN), and in one of 11 (9.1%) JAK2V617F negative patients diagnosed with MPN. We suggest that analysis of CALR mutations should be performed in JAK2V617F negative BCS and PVT patients... |
Note: | Carta a l'editor |
Note: | Reproducció del document publicat a: https://doi.org/10.3324/haematol.2014.120857 |
It is part of: | Haematologica, 2015, vol. 100, num. 6, p. e226-8 |
URI: | http://hdl.handle.net/2445/105544 |
Related resource: | https://doi.org/10.3324/haematol.2014.120857 |
ISSN: | 0390-6078 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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