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http://hdl.handle.net/2445/105633
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DC Field | Value | Language |
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dc.contributor.author | Slebe, Felipe | - |
dc.contributor.author | Rojo, Federico | - |
dc.contributor.author | Vinaixa Crevillent, Maria | - |
dc.contributor.author | García Rocha, Mar | - |
dc.contributor.author | Testoni, Giorgia | - |
dc.contributor.author | Guiu, Marc | - |
dc.contributor.author | Planet, Evarist | - |
dc.contributor.author | Samino Gené, Sara | - |
dc.contributor.author | Arenas, Enrique J. | - |
dc.contributor.author | Beltran, Antoni | - |
dc.contributor.author | Rovira, Ana | - |
dc.contributor.author | Lluch Hernández, Ana | - |
dc.contributor.author | Salvatella i Giralt, Xavier | - |
dc.contributor.author | Yanes, Oscar | - |
dc.contributor.author | Albanell Mestres, Joan | - |
dc.contributor.author | Guinovart, Joan J. (Joan Josep), 1947- | - |
dc.contributor.author | Gomis i Cabré, Roger | - |
dc.date.accessioned | 2017-01-16T10:47:14Z | - |
dc.date.available | 2017-01-16T10:47:14Z | - |
dc.date.issued | 2016-04-05 | - |
dc.identifier.uri | http://hdl.handle.net/2445/105633 | - |
dc.description.abstract | The mechanisms that allow breast cancer (BCa) cells to metabolically sustain rapid growth are poorly understood. Here we report that BCa cells are dependent on a mechanism to supply precursors for intracellular lipid production derived from extracellular sources and that the endothelial lipase (LIPG) fulfils this function. LIPG expression allows the import of lipid precursors, thereby contributing to BCa proliferation. LIPG stands out as an essential component of the lipid metabolic adaptations that BCa cells, and not normal tissue, must undergo to support high proliferation rates. LIPG is ubiquitously and highly expressed under the control of FoxA1 or FoxA2 in all BCa subtypes. The downregulation of either LIPG or FoxA in transformed cells results in decreased proliferation and impaired synthesis of intracellular lipids. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Macmillan | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1038/ncomms11199 | - |
dc.relation.ispartof | Nature Communications, 2016, vol. 7, num. 11199 | - |
dc.relation.uri | http://dx.doi.org/10.1038/ncomms11199 | - |
dc.rights | cc by (c) Slebe et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Hidrolases | - |
dc.subject.classification | Biologia molecular | - |
dc.subject.classification | Factors de transcripció | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Hydrolases | - |
dc.subject.other | Molecular biology | - |
dc.subject.other | Transcription factors | - |
dc.title | FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2017-01-05T09:14:02Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27045898 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
This item is licensed under a Creative Commons License