Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/105635
Title: | Stratification and therapeutic potential of PML in metastatic breast cancer |
Author: | Martín-Martín, Natalia Piva, Marco Urosevic, Jelena Aldaz, Paula Sutherland, James David Fernández-Ruiz, Sonia Arreal, Leire Torrano, Verónica Cortazar, Ana Rosa Planet, Evarist Guiu, Marc Radosevic Robin, Nina Garcia, Stephane Macías, Iratxe Salvador, Fernando Domenici, Giacomo Rueda, Oscar M. Zabala Letona, Amaia Arruabarrena-Aristorena, Amaia Zúñiga García, Patricia Caro Maldonado, Alfredo Valcarcel-Jimenez, Lorea Sánchez Mosquera, Pilar Varela Rey, Marta Martínez Chantar, Maria Luz Anguita, Juan Ibrahim, Yasir H. Scaltriti, Maurizio Lawrie, Charles H. Aransay, Ana M. Iovanna, Juan L. Baselga Torres, Josep, 1959- Caldas, Carlos Barrio, Rosa Serra, Violeta Vivanco, Maria d. M. Matheu, Ander Gomis i Cabré, Roger Carracedo, Arkaitz |
Keywords: | Càncer de mama Interacció cel·lular Breast cancer Cell interaction |
Issue Date: | 24-Aug-2016 |
Publisher: | Macmillan |
Abstract: | Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood. Here we show that PML is a novel target in aggressive breast cancer. The acquisition of aggressiveness and metastatic features in breast tumours is accompanied by the elevated PML expression and enhanced sensitivity to its inhibition. Interestingly, we find that STAT3 is responsible, at least in part, for the transcriptional upregulation of PML in breast cancer. Moreover, PML targeting hampers breast cancer initiation and metastatic seeding. Mechanistically, this biological activity relies on the regulation of the stem cell gene SOX9 through interaction of PML with its promoter region. Altogether, we identify a novel pathway sustaining breast cancer aggressiveness that can be therapeutically exploited in combination with PML-based stratification. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1038/ncomms12595 |
It is part of: | Nature Communications, 2016, vol. 7, p. 12595 |
URI: | http://hdl.handle.net/2445/105635 |
Related resource: | http://dx.doi.org/10.1038/ncomms12595 |
ISSN: | 2041-1723 |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) Publicacions de projectes de recerca finançats per la UE |
This item is licensed under a Creative Commons License