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Title: Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope
Author: Mikolcevic, Petra
Isoda, Michitaka
Shibuya, Hiroki
Barco Barrantes, Ivan del
Igea, Ana
Suja,José .A.
Shackleton, Sue
Watanabe, Yoshinori
Nebreda, Àngel R.
Keywords: Interacció cel·lular
Cell interaction
Issue Date: 30-Mar-2016
Publisher: Macmillan
Abstract: Cyclin-dependent kinases (CDKs) play key roles in cell cycle regulation. Genetic analysis in mice has revealed an essential role for Cdk2 in meiosis, which renders Cdk2 knockout (KO) mice sterile. Here we show that mice deficient in RingoA, an atypical activator of Cdk1 and Cdk2 that has no amino acid sequence homology to cyclins, are sterile and display meiotic defects virtually identical to those observed in Cdk2 KO mice including non-homologous chromosome pairing, unrepaired double-strand breaks, undetectable sex-body and pachytene arrest. Interestingly, RingoA is required for Cdk2 targeting to telomeres and RingoA KO spermatocytes display severely affected telomere tethering as well as impaired distribution of Sun1, a protein essential for the attachment of telomeres to the nuclear envelope. Our results identify RingoA as an important activator of Cdk2 at meiotic telomeres, and provide genetic evidence for a physiological function of mammalian Cdk2 that is not dependent on cyclins.
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It is part of: Nature Communications, 2016, vol. 7, p. 11084
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Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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