Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/105644
Title: JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling
Author: Recasens Alvarez, Carles
Ferreira, Ana
Milán, Marco
Keywords: Morfogènesi
Drosòfila
Morphogenesis
Drosophila
Issue Date: 3-Jan-2017
Publisher: Macmillan
Abstract: A stable pool of morphogen-producing cells is critical for the development of any organ or tissue. Here we present evidence that JAK/STAT signalling in the Drosophila wing promotes the cycling and survival of Hedgehog-producing cells, thereby allowing the stable localization of the nearby BMP/Dpp-organizing centre in the developing wing appendage. We identify the inhibitor of apoptosis dIAP1 and Cyclin A as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population. We also unravel an early role of JAK/STAT in guaranteeing Wingless-mediated appendage specification, and a later one in restricting the Dpp-organizing activity to the appendage itself. These results unveil a fundamental role of the conserved JAK/STAT pathway in limb specification and growth by regulating morphogen production and signalling, and a function of pro-survival cues and mitogenic signals in the regulation of the pool of morphogen-producing cells in a developing organ.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1038/ncomms13815
It is part of: Nature Communications, 2017, vol. 8, p. 13815
Related resource: http://dx.doi.org/10.1038/ncomms13815
URI: http://hdl.handle.net/2445/105644
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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