Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/105644
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dc.contributor.authorRecasens Álvarez, Carles-
dc.contributor.authorFerreira, Ana-
dc.contributor.authorMilán, Marco-
dc.date.accessioned2017-01-16T12:10:00Z-
dc.date.available2017-01-16T12:10:00Z-
dc.date.issued2017-01-03-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/2445/105644-
dc.description.abstractA stable pool of morphogen-producing cells is critical for the development of any organ or tissue. Here we present evidence that JAK/STAT signalling in the Drosophila wing promotes the cycling and survival of Hedgehog-producing cells, thereby allowing the stable localization of the nearby BMP/Dpp-organizing centre in the developing wing appendage. We identify the inhibitor of apoptosis dIAP1 and Cyclin A as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population. We also unravel an early role of JAK/STAT in guaranteeing Wingless-mediated appendage specification, and a later one in restricting the Dpp-organizing activity to the appendage itself. These results unveil a fundamental role of the conserved JAK/STAT pathway in limb specification and growth by regulating morphogen production and signalling, and a function of pro-survival cues and mitogenic signals in the regulation of the pool of morphogen-producing cells in a developing organ.-
dc.format.extent14 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherMacmillan-
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1038/ncomms13815-
dc.relation.ispartofNature Communications, 2017, vol. 8, p. 13815-
dc.rightscc by (c) Recasens et al., 2017-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/-
dc.sourceArticles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))-
dc.subject.classificationMorfogènesi-
dc.subject.classificationDrosòfila-
dc.subject.otherMorphogenesis-
dc.subject.otherDrosophila-
dc.titleJAK/STAT controls organ size and fate specification by regulating morphogen production and signalling-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.doihttp://dx.doi.org/10.1038/ncomms13815-
dc.date.updated2017-01-16T12:07:59Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid28045022-
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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