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DC Field | Value | Language |
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dc.contributor.author | Recasens Álvarez, Carles | - |
dc.contributor.author | Ferreira, Ana | - |
dc.contributor.author | Milán, Marco | - |
dc.date.accessioned | 2017-01-16T12:10:00Z | - |
dc.date.available | 2017-01-16T12:10:00Z | - |
dc.date.issued | 2017-01-03 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/105644 | - |
dc.description.abstract | A stable pool of morphogen-producing cells is critical for the development of any organ or tissue. Here we present evidence that JAK/STAT signalling in the Drosophila wing promotes the cycling and survival of Hedgehog-producing cells, thereby allowing the stable localization of the nearby BMP/Dpp-organizing centre in the developing wing appendage. We identify the inhibitor of apoptosis dIAP1 and Cyclin A as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population. We also unravel an early role of JAK/STAT in guaranteeing Wingless-mediated appendage specification, and a later one in restricting the Dpp-organizing activity to the appendage itself. These results unveil a fundamental role of the conserved JAK/STAT pathway in limb specification and growth by regulating morphogen production and signalling, and a function of pro-survival cues and mitogenic signals in the regulation of the pool of morphogen-producing cells in a developing organ. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Macmillan | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1038/ncomms13815 | - |
dc.relation.ispartof | Nature Communications, 2017, vol. 8, p. 13815 | - |
dc.rights | cc by (c) Recasens et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) | - |
dc.subject.classification | Morfogènesi | - |
dc.subject.classification | Drosòfila | - |
dc.subject.other | Morphogenesis | - |
dc.subject.other | Drosophila | - |
dc.title | JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.doi | http://dx.doi.org/10.1038/ncomms13815 | - |
dc.date.updated | 2017-01-16T12:07:59Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28045022 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
File | Description | Size | Format | |
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ncomms13815.pdf | 5.25 MB | Adobe PDF | View/Open |
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