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http://hdl.handle.net/2445/105786
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DC Field | Value | Language |
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dc.contributor.author | Wilke, Sarah | - |
dc.contributor.author | Jones, Paul W. | - |
dc.contributor.author | Müllerova, Hana | - |
dc.contributor.author | Vestbo, Jørgen | - |
dc.contributor.author | Tal-Singer, Ruth | - |
dc.contributor.author | Franssen, Frits M.E. | - |
dc.contributor.author | Agustí García-Navarro, Àlvar | - |
dc.contributor.author | Bakke, Per | - |
dc.contributor.author | Calverley, Peter M. | - |
dc.contributor.author | Coxson, Harvey O. | - |
dc.contributor.author | Crim, Courtney | - |
dc.contributor.author | Edwards, Lisa D. | - |
dc.contributor.author | Lomas, David A. | - |
dc.contributor.author | MacNee, William | - |
dc.contributor.author | Rennard, Stephen I. | - |
dc.contributor.author | Yates, Julie C. | - |
dc.contributor.author | Wouters, Emiel | - |
dc.contributor.author | Spruit, Martijn A. | - |
dc.date.accessioned | 2017-01-18T14:57:30Z | - |
dc.date.available | 2017-01-18T14:57:30Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 0040-6376 | - |
dc.identifier.uri | http://hdl.handle.net/2445/105786 | - |
dc.description.abstract | BACKGROUND: Poor health status has been associated with morbidity and mortality in patients with COPD. To date, the impact of changes in health status on these outcomes remains unknown. AIMS: To explore the relationship of clinically relevant changes in health status with exacerbation, hospitalisation or death in patients with COPD. METHODS: Characteristics and health status (St George's Respiratory Questionnaire, SGRQ) were assessed over a period of 3 years in 2138 patients with COPD enrolled in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study: a longitudinal, prospective, observational study. Associations between change in health status (=4 units in SGRQ score) during year 1 and time to first exacerbation, hospitalisation and death during 2-year follow-up were assessed using Kaplan-Meier plots and log-rank test. RESULTS: 1832 (85.7%) patients (age 63.4±7.0 years, 65.4% male, FEV1 48.7±15.6% predicted) underwent assessment at baseline and 1 year. Compared with those who deteriorated, patients with improved or stable health status in year 1 have a lower likelihood of exacerbation (HR 0.78 (95% CI 0.67 to 0.89), p<0.001 and 0.84 (0.73 to 0.97), p=0.016, respectively), hospitalisation (0.72 (0.58 to 0.90), p=0.004 and 0.77 (0.62 to 0.96), p=0.023, respectively) or dying (0.61 (0.39 to 0.95), p=0.027 and 0.58 (0.37 to 0.92), p=0.019, respectively) during 2-year follow-up. This effect persisted after stratification for age and the number of exacerbations and hospitalisations during the first year of the study. CONCLUSIONS: Patients with stable or improved health status during year 1 of ECLIPSE had a lower likelihood of exacerbation, hospitalisation or dying during 2-year follow-up. Interventions that stabilise and improve health status may also improve outcomes in patients with COPD. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BMJ Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1136/thoraxjnl-2014-205697 | - |
dc.relation.ispartof | Thorax, 2015, vol. 70, num. 5, p. 420-425 | - |
dc.relation.uri | https://doi.org/10.1136/thoraxjnl-2014-205697 | - |
dc.rights | (c) BMJ Publishing Group, 2015 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Malalties pulmonars obstructives cròniques | - |
dc.subject.classification | Salut pública | - |
dc.subject.classification | Mortalitat | - |
dc.subject.classification | Morbiditat | - |
dc.subject.other | Chronic obstructive pulmonary diseases | - |
dc.subject.other | Public health | - |
dc.subject.other | Mortality | - |
dc.subject.other | Morbidity | - |
dc.title | One-year change in health status and subsequent outcomes in COPD | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 661095 | - |
dc.date.updated | 2017-01-18T14:57:30Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25782757 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
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661095.pdf | 467.94 kB | Adobe PDF | View/Open |
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